2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. Type II TRK inhibitor 1

Type II TRK inhibitor 1 是一种有效的 TRK 抑制剂，可抑制各种 TRK 融合蛋白变体和野生型。Type II TRK inhibitor 1 对携带 CD74-TRKAG667C 和 ETV6-TRKCG696C 融合蛋白的 Ba/F3 细胞具有抗增殖活性，IC 值为 50 分别为 6 nM 和 1.7 nM。Type II TRK inhibitor 1 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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Type II TRK inhibitor 1 Chemical Structure

Type II TRK inhibitor 1 Chemical Structure

CAS No. : 2937543-72-9

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Type II TRK inhibitor 1 相关抗体

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TrkA TrkB TrkC Trk

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type. Type II TRK inhibitor 1 exhibits antiproliferative activity against Ba/F3 cells harboring CD74-TRKAG667C and ETV6-TRKCG696C fusion proteins with IC50s of 6 nM and 1.7 nM, respectively[1]. Type II TRK inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

TrkA

 

TrkC

 

体外研究
(In Vitro)

Type II TRK inhibitor 1 (compound 7b) (3.1-800 nM; 2 h) 抑制 TRKA，PLCγ1 和 ERK 的磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Type II TRK inhibitor 1 相关抗体:

Western Blot Analysis[1]

Cell Line: Ba/F3 engineered cells harboring CD74-TRKA, CD74-TRKAG667C, and CD74-TRKAG595R
Concentration: 0 nM, 3.1 nM, 12.5 nM, 50 nM, 200 nM, 800 nM
Incubation Time: 24 hours
Result: Decreased the protein level of p-TRKA, p-PLCγ1, p-ERK in cells.
分子量

670.68

Formula

C35H33F3N8O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Type II TRK inhibitor 1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Type II TRK inhibitor 12937543-72-9Trk ReceptorTropomyosin related kinase receptorTRK fusion proteinantiproliferative activityBa/F3 cellsInhibitorinhibitorinhibit

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