2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. TZD18

TZD18 是一种具有口服活性的，有效的 PPARα 和 PPARγ 双重激动剂，对 PPARα、PPARγ、PPARδ 的 IC50 值分别为 0.028、0.057、>10 µM。TZD18 可降低糖尿病小鼠的血浆葡萄糖和甘油三酯水平。TZD18 具有用于 2 型糖尿病研究的潜力。

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TZD18 Chemical Structure

TZD18 Chemical Structure

CAS No. : 228577-00-2

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TZD18 相关抗体

Top Publications Citing Use of Products

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PPARα PPARβ/δ PPARγ PPAR PPARδ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TZD18 is a potent and orally active PPARα and PPARγ dual agonist with IC50 values of 0.028, 0.057, >10 µM for PPARα, PPARγ, PPARδ, respectively. TZD18 reduces plasma levels of both glucose and triglycerides in diabetic mice. TZD18 has the potential for the research of type 2 diabetes[1].

IC50 & Target[1]

hPPARα

0.028 μM (IC50)

hPPARγ

0.057 μM (IC50)

PPARδ

>10 μM (IC50)

体内研究
(In Vivo)

TZD18 (3, 10 mg/kg; p.o.; daily for 11 days) 可完全纠正糖尿病小鼠血浆中升高的葡萄糖和甘油三酯水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 12-13 weeks, Male db/db and nondiabetic db/+ (lean) mice (type 2 diabetes) [1]
Dosage: 3, 10 mg/kg
Administration: P.o.; daily for 11 days
Result: Reduced hyperglycemia and plasma triglyceride levels.
分子量

477.57

Formula

C27H27NO5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TZD18 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TZD18228577-00-2TZD 18TZD-18PPARPeroxisome proliferator-activated receptorsglucosetriglyceridesorally activetype 2 diabetesInhibitorinhibitorinhibit

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HY-121798
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