2. Anti-infection
  3. HIV
  4. UC-781

UC-781 (NSC 675186) 是一种高效、选择性的人类免疫缺陷病毒 HIV-1 非核苷类逆转录酶抑制剂 (NNRTI)，IC50 值为 5 nM。UC-781 在低 PH 或不同温度下是稳定的。UC-781 具有抗病毒活性和耐药性。

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UC-781 Chemical Structure

UC-781 Chemical Structure

CAS No. : 178870-32-1

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UC-781 相关抗体

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查看 HIV 亚型特异性产品:

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HIV HIV-1 HIV-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UC-781 (NSC 675186) is a highly potent and selective nonnucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with an IC50 value of 5 nM. UC-781 is stable under low PH or various temperatures conditions. UC-781 has antiviral activity and resistance[1][2][3].

IC50 & Target[1]

HIV-1

0.005 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MRC5 IC50
> 64 μM
Compound: UC781
Trypanocidal activity against nifurtimox-sensitive Trypanosoma cruzi Tulahuen CL2 infected in human MRC5 SV2 cells assessed as parasite growth inhibition after 168 hrs by beta-galactosidase assay
Trypanocidal activity against nifurtimox-sensitive Trypanosoma cruzi Tulahuen CL2 infected in human MRC5 SV2 cells assessed as parasite growth inhibition after 168 hrs by beta-galactosidase assay
[PMID: 25199582]
MRC5 IC50
> 64 μM
Compound: UC781
Cytotoxicity against human MRC5 SV2 cells assessed as reduction in cell growth after 72 hrs
Cytotoxicity against human MRC5 SV2 cells assessed as reduction in cell growth after 72 hrs
[PMID: 25199582]
MT2 CC50
> 100 μM
Compound: UC-781
Cytotoxicity against human MT2 cells by MTT assay
Cytotoxicity against human MT2 cells by MTT assay
[PMID: 16298131]
MT2 EC50
0.002 μM
Compound: UC-781
Antiviral activity against HIV1 3B in MT2 cells by MTT assay
Antiviral activity against HIV1 3B in MT2 cells by MTT assay
[PMID: 16298131]
MT2 CC50
41 μM
Compound: 3
Cytotoxicity against human MT2 cells by MTT assay
Cytotoxicity against human MT2 cells by MTT assay
[PMID: 17918923]
TZM CC50
> 100 μM
Compound: UC781
Cytotoxicity against human TZM-bl cells assessed as cell viability after 48 hrs by WST1 assay
Cytotoxicity against human TZM-bl cells assessed as cell viability after 48 hrs by WST1 assay
[PMID: 25199582]
体外研究
(In Vitro)

UC-781 (0.05、0.2 和 0.5 % UC-781 补充凝胶；10 d) 从凝胶制剂中释放出来，并清除 CEM 细胞中的 HIV-1[1]。
UC-781 (3.75 -30 μM) 抑制蜡样芽孢杆菌的生长 (约 50 %)[1]。
UC-781 抑制 CEM T 细胞中的 HIV-1 (ⅢB) 活性 (EC50=6 nM; IC50=23 nM)。UC-781 抑制单核细胞来源的树突状细胞 (MO-DC) 和自体 CD4+ T 细胞中的 HIV 活性，EC50 值分别为 550 nM 和 1588 nM[2]。
UC-781 (1000 nM；24 h) 有效地防止或阻止了单核细胞来源的树突状细胞和自体 CD4+ T 细胞感染 HIV[2]。
UC-781 (0.001-1000 µM；2 h) 抑制病毒转移和宫颈外植体感染 HIV-1BaL[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

UC-781 相关抗体:
体内研究
(In Vivo)

UC-781 (100 µl 5% UC-781 补充凝胶；阴道内；一天一次持续 10 天) 从凝胶制剂中释放出来，对雌兔正常组织显示低毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female rabbit (~1200 g; 10 weeks old)[1].
Dosage: 100 µl 5% UC-781 replens gel.
Administration: Intravaginal; once daily for 10 days.
Result: Released from gel preparation and had normal histology without significant increases inflammatory cells in rabbits.
Clinical Trial
分子量

335.85

Formula

C17H18ClNO2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UC-781 相关分类

  • 摩尔计算器

  • 稀释计算器

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UC-781178870-32-1NSC 675186UC781UC 781NSC675186NSC-675186HIVHuman immunodeficiency virusCEMMO-DCCD4+RabbitInhibitorinhibitorinhibit

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目录号：
HY-15351
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