2. MAPK/ERK Pathway Stem Cell/Wnt Apoptosis PI3K/Akt/mTOR
  3. ERK TNF Receptor Akt
  4. UNC10245380

UNC10245380 是一种 CIB1 抑制剂，IC50 值为 8 μM。同时 UNC10245380 也可抑制 AKT 和 ERK 的磷酸化，并上调TRAIL-R1/D5 表达。 UNC10245380 可特异性杀死具 CIB1 依赖性的癌细胞，展示了其在 CIB1 探针开发和癌症研究中的潜在应用价值。

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UNC10245380 Chemical Structure

UNC10245380 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

UNC10245380 相关抗体

Top Publications Citing Use of Products

查看 ERK 亚型特异性产品:

查看所有亚型
ERK ERK1 ERK2 ERK5 ERK8

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UNC10245380 is a CIB1 inhibitor with an IC50 value of 8 μM. Additionally, UNC10245380 inhibits the phosphorylation of AKT and ERK and upregulates the expression of TRAIL-R1/D5. UNC10245380 selectively induces cell death in CIB1-dependent cancer cells, highlighting its potential utility in the development of CIB1-targeted probes and cancer research[1][2].

IC50 & Target

IC50 = 8 μM (Calcium and Integrin Binding Protein 1 (CIB1))[1]
体外研究
(In Vitro)

UNC10245380 (30 μM, 24 小时) 在 CIB1 耗竭敏感的三阴性乳腺癌 (TNBC) 细胞中显示出特异性杀伤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

UNC10245380 相关抗体:

Cell Viability Assay[1]

Cell Line: CIB1 depletion-sensitive (MDA461, MDA468) and -insensitive (MDA231) TNBC cells
Concentration: 30 μM
Incubation Time: 24 h
Result: Showed significant cell killing activity in both CIB1-depletion-sensitive (MDA-MB-461, and MDA-MB-468) cell lines, but showed no activity in the CIB1-depletion-insensitive (MDA-MB-231) cell line.

Western Blot Analysis[1]

Cell Line: MDA-MB-468, MDA-MB-436, MDA-MB-231, BT-549 cells
Concentration: 30 μM
Incubation Time: 24 h
Result: Inhibited AKT and ERK phosphorylation in CIB1 depletion-sensitive cell lines, but not insensitive cell lines.
分子量

578.12

Formula

C30H32ClN5O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UNC10245380 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC10245380UNC 10245380UNC-10245380ERKTNF ReceptorAktExtracellular signal regulated kinasesTumor Necrosis Factor ReceptorTNFRPKBProtein kinase BTNBC cellsAnti-cancer activityCancerInhibitorinhibitorinhibit

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目录号：
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