2. PROTAC Immunology/Inflammation
  3. PROTACs STING
  4. UNC9036

UNC9036 是 STING 的 PROTAC 降解剂，其 DC50 值为 227 nM。UNC9036 介导的STING 降解依赖于蛋白酶体 VHL途径。(Structure Note: Red, STING agonist diABZI (HY-112921A); Blue, VHL ligand VH032 (HY-120217); Black, linker) .

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UNC9036 Chemical Structure

UNC9036 Chemical Structure

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UNC9036 相关抗体

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UNC9036 is a PROTAC-based STING degrader, with a DC50 of 227 nM. UNC9036-mediated STING degradation is proteasome and VHL dependent (Structure Note: Red, STING agonist diABZI (HY-112921A); Blue, VHL ligand VH032 (HY-120217); Black, linker)[1].

IC50 & Target

VHL

 

体外研究
(In Vitro)

UNC9036 介导的降解通过多步骤机制发生：1: diABZI PROTAC结合并激活STING，激活的STING被磷酸化；2: VHL配体招募VHL靶向磷酸化的 STING 进行蛋白酶体降解。
在UNC9036处理条件下，VHL耗尽部分挽救了STING表达[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

UNC9036 相关抗体:

Western Blot Analysis[1].

Cell Line: Whole cell lysates (WCL) derived from Caki-1 cells.
Concentration: 1 μM.
Incubation Time: 0-24 h.
Result: Degrades protein levels of STING time-dependently.
分子量

1418.71

Formula

C73H95N17O11S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UNC9036 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC9036UNC 9036UNC-9036PROTACsSTINGStimulator of Interferon GenesTMEM173MITAERISMPYSVHLdiABZIWCLInhibitorinhibitorinhibit

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产品名称：
UNC9036
目录号：
HY-158048
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