2. Epigenetics
  3. Epigenetic Reader Domain
  4. UNC926 hydrochloride

UNC926 hydrochloride 是一种 methyl-lysine (Kme) reader domain 抑制剂，可特异性抑制 L3MBTL1，其 IC50 为 3.9 μM。

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UNC926 hydrochloride Chemical Structure

UNC926 hydrochloride Chemical Structure

CAS No. : 1782573-49-2

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UNC926 hydrochloride 的其他形式现货产品:

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UNC926 hydrochloride 相关抗体

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  • 生物活性

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生物活性

UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM[1].

IC50 & Target

IC50: 3.9 μM (L3MBTL1), 3.2 μM (L3MBTL3), 15.6 μM (L3MBTL4)[1]
体外研究
(In Vitro)

UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7[1].
UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

UNC926 hydrochloride 相关抗体:
分子量

373.72

Formula

C16H22BrClN2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UNC926 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

UNC9261782573-49-2UNC 926UNC-926Epigenetic Reader DomainL3MBTL1methyl-lysineL3MBTL3H4K20me13xMBTInhibitorinhibitorinhibit

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产品名称：
UNC926 hydrochloride
目录号：
HY-16510A
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