2. Metabolic Enzyme/Protease Neuronal Signaling
  3. FAAH
  4. URB694

URB694 是一种氨基甲酸酯 FAAH 抑制剂，不可逆地将 FAAH 活性位点中的亲核催化丝氨酸氨基甲酰化。URB694 具有抗抑郁样活性和心脏保护作用。URB694 可用于制备 11C-Carbonyl-URB694，用于大脑 FAAH 的体内正电子发射断层扫描 (PET) 成像研究。

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URB694 Chemical Structure

URB694 Chemical Structure

CAS No. : 904672-77-1

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URB694 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare 11C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH[1][2].

体内研究
(In Vivo)

URB694 (0.3 mg/kg; i.p.) 增加了 HAB 大鼠张开双臂的时间，且不影响整体运动活动[1]。
URB694 (0.3 mg/kg; i.p.) 减少 HAB 大鼠中盐酸异丙肾上腺素 (ISOP; HY-B0468) 诱导的心律失常发生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5-month-old male Wistar rats (350-450 g) selectively bred for high (HAB) and low (LAB) anxiety-related behavior in the elevated plus-maze test or non-selected rats (NAB)[1]
Dosage: 0.3 mg/kg
Administration: Administered intraperitoneally to rats in a volume of 0.5 mL/kg
Result: Significantly increased the time spent by HAB rats on the open arms.
Had no effects on NABs’ and LABs’ behavioral performance in the elevated plus maze test.
Animal Model: HAB, NAB and LAB rats[1]
Dosage: 0.3 mg/kg
Administration: Received the i.p. injection 30 min before ISOP (0.02 mg/kg)
Result: Significantly reduced ISOP-induced arrhythmia occurrence in HAB rats compared to vehicle pretreatment condition.
Had no significant effects in NAB and LAB rats.
分子量

311.37

Formula

C19H21NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

URB694 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

URB694904672-77-1URB 694URB-694FAAHFatty acid amide hydrolaseantidepressantcardioprotectivepositron emission tomographyPETInhibitorinhibitorinhibit

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