2. 天然产物
  3. 疾病研究领域 植物 生物碱
  4. 爵床科 神经系统疾病 其他科 吡咯类生物碱
  5. 鸭嘴花
  6. Vasicinone

Vasicinone  (Synonyms: (-)-Vasicinone)

目录号: HY-N1100 纯度: 99.89%
COA 产品使用指南

摩尔计算器

Vasicinone 是从鸭嘴花中分离得到的喹唑啉类生物碱。Vasicinone 是一种潜在的研究帕金森病和其他氧化应激相关神经退行性疾病的化合物。

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Vasicinone Chemical Structure

Vasicinone Chemical Structure

CAS No. : 486-64-6

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规格 价格 是否有货 数量
1 mg ￥1000
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5 mg ￥2400
In-stock
10 mg ￥3800
In-stock
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100 mg   询价  

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Customer Review

Other Forms of Vasicinone:

Vasicinone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HL-60 IC50
67.77 μM
Compound: 9b
Cytotoxicity against human HL60 cells assessed as reduction in cell viability by trypan blue method
Cytotoxicity against human HL60 cells assessed as reduction in cell viability by trypan blue method
[PMID: 29229205]
体外研究
(In Vitro)

Vasicinone (1~30 μM; 24 hours; SH-SY5Y cells) significantly reverses the paraquat-induced reduction in cell viability[1].
Vasicinone (10 and 15 μM; 24 hours; SH-SY5Y cells) abates the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway, dose-dependently reduces the percentage of apoptotic cells and is capable of rescuing paraquat-induced apoptotic death[1].
Vasicinone (10 and 15 μM; SH-SY5Y cells) attenuates the paraquat-induced accumulation of reactive oxygen species (ROS) and attenuates the paraquat-induced expression of apoptotic proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Vasicinone 相关抗体:

Cell Viability Assay[1]

Cell Line: SH-SY5Y cells
Concentration: 1~30 µM
Incubation Time: 24 hours
Result: Significantly reversed the paraquat-induced reduction in cell viability.

Western Blot Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 10 and 15 µM
Incubation Time: 24 hours
Result: Abated the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway.

Apoptosis Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 10 and 15 µM
Incubation Time: 24 hours
Result: Dose-dependently reduced the percentage of apoptotic cells.
分子量

202.21

Formula

C11H10N2O2
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (247.27 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.9454 mL 24.7268 mL 49.4535 mL
5 mM 0.9891 mL 4.9454 mL 9.8907 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.89%

COA (290 KB) HNMR (163 KB) CNMR (117 KB) RP-HPLC (238 KB)

产品使用指南 (1538 KB)
参考文献

Vasicinone 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.9454 mL 24.7268 mL 49.4535 mL 123.6338 mL
5 mM 0.9891 mL 4.9454 mL 9.8907 mL 24.7268 mL
10 mM 0.4945 mL 2.4727 mL 4.9454 mL 12.3634 mL
15 mM 0.3297 mL 1.6485 mL 3.2969 mL 8.2423 mL
20 mM 0.2473 mL 1.2363 mL 2.4727 mL 6.1817 mL
25 mM 0.1978 mL 0.9891 mL 1.9781 mL 4.9454 mL
30 mM 0.1648 mL 0.8242 mL 1.6485 mL 4.1211 mL
40 mM 0.1236 mL 0.6182 mL 1.2363 mL 3.0908 mL
50 mM 0.0989 mL 0.4945 mL 0.9891 mL 2.4727 mL
60 mM 0.0824 mL 0.4121 mL 0.8242 mL 2.0606 mL
80 mM 0.0618 mL 0.3091 mL 0.6182 mL 1.5454 mL
100 mM 0.0495 mL 0.2473 mL 0.4945 mL 1.2363 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vasicinone486-64-6(-)-VasicinoneOthersquinazolinealkaloidAdhatodavasicaplantParkinsonoxidativestressneurodegenerativedisordersInhibitorinhibitorinhibit

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