2. Protein Tyrosine Kinase/RTK Anti-infection Metabolic Enzyme/Protease
  3. VEGFR Bacterial Dihydrofolate reductase (DHFR) Fungal
  4. VEGFR-2/DHFR-IN-1

VEGFR-2/DHFR-IN-1 (compound 8b) 是 VEGFR-2 和 DHFR 的抑制剂，其 IC50 值分别为 0.384 和 7.881 μM。VEGFR-2/DHFR-IN-1 对大肠埃希菌，粪链球菌，肠沙门氏菌，金黄色酿脓葡萄球菌，MSSA 和 MRSA 显示了良好的抗菌活性，MIC 值分别为 16，16，16，8 和 16 μg/mL。VEGFR-2/DHFR-IN-1 对 C26，HepG2 和 CF7 癌细胞系具有良好的细胞毒性，IC50 值为 2.97-7.12 μM。VEGFR-2/DHFR-IN-1 可用于癌症的研究。

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VEGFR-2/DHFR-IN-1 Chemical Structure

VEGFR-2/DHFR-IN-1 Chemical Structure

CAS No. : 2831498-15-6

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VEGFR-2/DHFR-IN-1 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.384 and 7.881 μM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA and MRSA with MIC values of 16, 16, 16, 8, and 16 μg/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 2.97-7.12 μM. VEGFR-2/DHFR-IN-1 can be used for the research of cancer[1].

IC50 & Target

VEGFR-2

0.384 μM (IC50)

DHFR

7.881 μM (IC50)

体外研究
(In Vitro)

VEGFR-2/DHFR-IN-1 (2-1024 μg/mL; 18-72 h) shows antibacterial and antifungal activities with MIC values of 16, 64, 16, 16, 8, 16, 64 and 256 μg/mL for Escherichia coli, Pseudomonas aeruginosa, Streptococcus faecalis, Salmonella enterica, MSSA, MRSA, Candida albicans and Aspergillus niger, respectively[1].
VEGFR-2/DHFR-IN-1 (0.5-100 μM; 48 h) exhibits anticancer activities[1].
VEGFR-2/DHFR-IN-1 (0-100 μM; 30 min) shows DHFR and VEGFR-2 inhibitory activities with IC50s of 7.881 and 0.384 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VEGFR-2/DHFR-IN-1 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: C26, HepG2, MCF7 and H69PR cell lines
Concentration: 0.5, 1, 5, 10, 25, 50, 80 and 100 μM
Incubation Time: 48 hours
Result: Showed anticancer activities to C26, HepG2, MCF7 and H69PR cells with IC50s of 2.97, 7.12, 3.58 and 12.79 μM, respectively.
分子量

371.81

Formula

C20H18ClNO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VEGFR-2/DHFR-IN-1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2/DHFR-IN-12831498-15-6VEGFRBacterialDihydrofolate reductase (DHFR)FungalVascular endothelial growth factor receptor2 NaphthamidederivativemicrowavepaclitaxelciprofloxacinPTXsorafenibanticancerantibacterialsilicoInhibitorinhibitorinhibit

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