2. Apoptosis Protein Tyrosine Kinase/RTK
  3. Apoptosis Necroptosis VEGFR
  4. VEGFR-2-IN-46

VEGFR-2-IN-46 (compound 4d) 是一种有效的 VEGFR-2 抑制剂，其 EC50 值为 67.0 nM。VEGFR-2-IN-46 表现出细胞毒性和诱导细胞周期停滞在 G2/M。VEGFR-2-IN-46 诱导细胞坏死 (necrosis) 和细胞凋亡 (apoptosis)。

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VEGFR-2-IN-46 Chemical Structure

VEGFR-2-IN-46 Chemical Structure

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VEGFR-2-IN-46 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VEGFR-2-IN-46 (compound 4d) is a potent VEGFR-2 inhibitor with an EC50 value of 67.0 nM. VEGFR-2-IN-46 shows cytotoxicity and induces cell cycle arrest at the G2/M phase. VEGFR-2-IN-46 induces necrosis and apoptosis[1].

体外研究
(In Vitro)

VEGFR-2-IN-46 (compound 4d) 对 HT-29、HeLa、HepG2、MCF10A 细胞表现出细胞毒性，IC50 值分别为 501、34.3、25.0、128.7 µM[1]。
VEGFR-2-IN-46 (25 µM; 72 h) 诱导细胞周期停滞在 G2/M 期，并诱导 HepG2 细胞坏死、凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VEGFR-2-IN-46 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HT-29, HeLa, HepG2, MCF10A cells
Concentration:
Incubation Time:
Result: Showed cytotoxicity with IC50s of 501, 34.3, 25.0, 128.7 µM for HT-29, HeLa, HepG2, MCF10A cells, respectively.

Cell Cycle Analysis[1]

Cell Line: HepG2 cells
Concentration: 25 µM
Incubation Time: 72 h
Result: Induced cell cycle arrest at G2/M phase with the proportion of G2/M phase cell arrest at 79.7%.

Apoptosis Analysis[1]

Cell Line: HepG2 cells
Concentration: 25 µM
Incubation Time: 72 h
Result: Induced necrosis and apoptosis with the proportion of necrotic, and apoptotic cells of 46.6% and 32.6%, respectively.
分子量

418.47

Formula

C23H18N2O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VEGFR-2-IN-46 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-46ApoptosisNecroptosisVEGFRVascular endothelial growth factor receptorcytotoxicitynecrosisapoptosisHepG2 cellsG2/M phaseInhibitorinhibitorinhibit

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目录号：
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