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  6. Vernolide B

Vernolide-B 具有细胞毒性 (对于 KB、NCI-661 和 HeLa 细胞的 ED50s 分别为 3.78、5.88、6.42 μg/mL)。Vernolide B 是倍半萜内酯，可以从 Vernonia cinerea 中分离出来。

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Vernolide B Chemical Structure

Vernolide B Chemical Structure

CAS No. : 618860-58-5

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规格 价格 是否有货
1 mg ￥3675
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Vernolide B 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vernolide-B has cytoxicity (ED50s: 3.78, 5.88, 6.42 μg/mL for KB, NCI-661, and HeLa cells respectively). Vernolide B is sesquiterpene lactone that can be isolated from Vernonia cinerea[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
12.8 μM
Compound: 7
Inhibition of TNFalpha-induced NF-kappaB activity expressed in human HEK 293 cells after 6 hrs by luciferase reporter gene assay
Inhibition of TNFalpha-induced NF-kappaB activity expressed in human HEK 293 cells after 6 hrs by luciferase reporter gene assay
[PMID: 22850207]
MCF7 IC50
7.6 μM
Compound: 10
Antiproliferative activity against human MCF7 cells for 72 hrs by cyquant assay
Antiproliferative activity against human MCF7 cells for 72 hrs by cyquant assay
[PMID: 26331426]
MDA-MB-231 IC50
6.6 μM
Compound: 10
Antiproliferative activity against human MDA-MB-231 cells for 72 hrs by cyquant assay
Antiproliferative activity against human MDA-MB-231 cells for 72 hrs by cyquant assay
[PMID: 26331426]
NIH3T3 IC50
7.9 μM
Compound: 10
Cytotoxicity against mouse NIH/3T3 cells after 72 hrs by cyquant cells
Cytotoxicity against mouse NIH/3T3 cells after 72 hrs by cyquant cells
[PMID: 26331426]
RAW264.7 IC50
1.2 μM
Compound: 7
Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method
Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method
[PMID: 22850207]
SF-295 IC50
8.2 μM
Compound: 10
Antiproliferative activity against human SF295 cells for 72 hrs by cyquant assay
Antiproliferative activity against human SF295 cells for 72 hrs by cyquant assay
[PMID: 26331426]
U-251 IC50
3.2 μM
Compound: 10
Inhibition of Stat3 dimer DNA binding activity in human U251MG cells nuclear extract after 1.5 hrs by EMSA using radiolabeled probe hSIE
Inhibition of Stat3 dimer DNA binding activity in human U251MG cells nuclear extract after 1.5 hrs by EMSA using radiolabeled probe hSIE
[PMID: 26331426]
U-251 IC50
3.4 μM
Compound: 10
Antiproliferative activity against human U251MG cells for 72 hrs by cyquant assay
Antiproliferative activity against human U251MG cells for 72 hrs by cyquant assay
[PMID: 26331426]
U-373MG ATCC IC50
4.1 μM
Compound: 10
Inhibition of Stat3 dimer DNA binding activity in human U373MG cells nuclear extract after 1.5 hrs by EMSA using radiolabeled probe hSIE
Inhibition of Stat3 dimer DNA binding activity in human U373MG cells nuclear extract after 1.5 hrs by EMSA using radiolabeled probe hSIE
[PMID: 26331426]
U-373MG ATCC IC50
6.6 μM
Compound: 10
Antiproliferative activity against human U373MG cells for 72 hrs by cyquant assay
Antiproliferative activity against human U373MG cells for 72 hrs by cyquant assay
[PMID: 26331426]
分子量

434.48

Formula

C23H30O8
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Vernolide B 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

Keywords:

Vernolide B618860-58-5OthersSesquiterpene lactoneanticancercytoxicityInhibitorinhibitorinhibit

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