2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Apoptosis Reactive Oxygen Species
  4. Verrucarin A

Verrucarin A  (Synonyms: Muconomycin A)

目录号: HY-107426 纯度: 99.89%
COA 产品使用指南

摩尔计算器

Verrucarin A (Muconomycin A) 是一种 D 型大环真菌毒素，来源于Myrothecium verrucaria，是一种蛋白质合成 (protein synthesis) 的抑制剂。Verrucarin A 抑制白血病细胞系生长，激活巨噬细胞 caspases、凋亡和炎症信号。Verrucarin A 能有效提高 p38 MAPK 的磷酸化，降低 ERK/Akt 的磷酸化。Verrucarin A 通过 p21 和 p53 的诱导引起细胞周期调控的解除。

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Verrucarin A Chemical Structure

Verrucarin A Chemical Structure

CAS No. : 3148-09-2

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规格 价格 是否有货 数量
1 mg ￥2000
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Customer Review

Verrucarin A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Verrucarin A (Muconomycin A), a Type D macrocyclic mycotoxin derived from the pathogen fungus Myrothecium verrucaria, is an inhibitor of protein synthesis. Verrucarin A inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HL-60 IC50
0.2 ng/mL
Compound: 3
Cytotoxicity against human HL60 cells after 72 hrs by WST8 assay
Cytotoxicity against human HL60 cells after 72 hrs by WST8 assay
[PMID: 11277768]
K562 IC50
0.003 μM
Compound: 14
Cytotoxicity against human K562 cells by disk diffusion soft agar colony formation assay
Cytotoxicity against human K562 cells by disk diffusion soft agar colony formation assay
[PMID: 31117520]
L1210 IC50
0.35 ng/mL
Compound: 3
Cytotoxicity against mouse L1210 cells after 72 hrs by WST8 assay
Cytotoxicity against mouse L1210 cells after 72 hrs by WST8 assay
[PMID: 11277768]
SW 1116 IC50
0.0018 μM
Compound: 14
Cytotoxicity against human SW1116 cells by disk diffusion soft agar colony formation assay
Cytotoxicity against human SW1116 cells by disk diffusion soft agar colony formation assay
[PMID: 31117520]
体外研究
(In Vitro)

Verrucarin A (0-0.6 μM/ml; 24-48 hours)-induces time- and dose-dependent growth inhibition in MCF-7 cells[1].
Verrucarin A increases the levels of reactive oxygen species (ROS), and subsequently induces mitochondrial membrane potential (Δψm) loss, leading to the increase of Bax/Bcl-2 ratio, cytochrome c release, caspase activation, PARP degradation, and apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Verrucarin A 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF-7 cells
Concentration: 0-0.6 μM/ml
Incubation Time: 24 and 48 hours
Result: Growth of MCF-7 cells is significantly inhibited in a dose- and time-dependent manner, with the IC50s of 0.41 and 0.29 μM/ml for 24- and 48-h treatment periods, respectively.
分子量

502.55

Formula

C27H34O9
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 10 mg/mL (19.90 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9899 mL 9.9493 mL 19.8985 mL
5 mM 0.3980 mL 1.9899 mL 3.9797 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.89%

COA (291 KB) RP-HPLC (1071 KB)

产品使用指南 (1538 KB)
参考文献

Verrucarin A 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9899 mL 9.9493 mL 19.8985 mL 49.7463 mL
5 mM 0.3980 mL 1.9899 mL 3.9797 mL 9.9493 mL
10 mM 0.1990 mL 0.9949 mL 1.9899 mL 4.9746 mL
15 mM 0.1327 mL 0.6633 mL 1.3266 mL 3.3164 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Verrucarin A3148-09-2Muconomycin AApoptosisReactive Oxygen SpeciesmitochondrialmembranedegradationinflammatoryphosphorylationmacrophagesInhibitorinhibitorinhibit

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