2. Apoptosis Metabolic Enzyme/Protease
  3. Apoptosis Endogenous Metabolite
  4. Violacein

Violacein 是微生物的次级代谢物，具有较强的抗癌活性和低副作用。Violacein 具有抗氧化活性。凋亡诱导剂。

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Violacein Chemical Structure

Violacein Chemical Structure

CAS No. : 548-54-9

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1 mg ￥5850
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Violacein 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer[1][2].

IC50 & Target

Microbial Metabolite

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Caco-2 IC50
> 1.5 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) Caco2 cells after 24 to 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) Caco2 cells after 24 to 48 hr by MTT assay
10.1007/s00044-011-9654-9
DLD-1 IC50
> 1.5 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) DLD1 cells after 24 to 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) DLD1 cells after 24 to 48 hr by MTT assay
10.1007/s00044-011-9654-9
HCT-116 IC50
> 1.5 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) HCT116 cells after 24 to 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) HCT116 cells after 24 to 48 hr by MTT assay
10.1007/s00044-011-9654-9
HT-29 IC50
> 1.5 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) HT-29 cells after 24 to 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) HT-29 cells after 24 to 48 hr by MTT assay
10.1007/s00044-011-9654-9
体外研究
(In Vitro)

Violacein (0.25-3 µM; 24h; HCT116 and HT29 cells) possesses anticancer activity in both 2D and 3D cell models[1].
Violacein decreases RTKs expression and disturbs signaling pathways in CRC cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Violacein 相关抗体:

Cell Viability Assay[1].

Cell Line: HCT116 and HT29 (1.8 × 104 cells/well-100 µL) cells.
Concentration: 0.25, 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 µM.
Incubation Time: 24h.
Result: In the 2D culture model, the violacein treatment reduced the cell viability, since there was a decrease in formazan production in the HT29 and HCT116 cell lines. Moreover, HT29 was more sensitive to violacein, as evidenced by the IC50 value (0.6 μM) compared to HCT116 (1.2 μM).
分子量

343.34

Formula

C20H13N3O3
CAS 号
性状

固体

颜色

Brown to black

结构分类
初始来源

Chromobacterium violaceum
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Violacein 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Violacein548-54-9ApoptosisEndogenous MetaboliteAnticancerMicroorganisms Secondary Metaboliteantioxidantapoptosiscolon cancer,Inhibitorinhibitorinhibit

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