1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor
  3. WAY-100289

WAY-100289 是一种口服的 5-HT3 受体 (5-HT3 receptor) 拮抗剂,对分离的大鼠迷走神经具有高亲和力,pA2 为 8.9。WAY-100289 可抑制麻醉和清醒大鼠的 Bezold-Jarisch 反射。

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WAY-100289 Chemical Structure

WAY-100289 Chemical Structure

CAS No. : 136013-69-9

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WAY-100289 is an orally active antagonist for 5-HT3 receptor, that exhibits high affinity to the isolated rat vagus nerves with pA2 of 8.9. WAY-100289 inhibits the Bezold-Jarisch reflex in anesthetized and awake rats[1].

IC50 & Target

5-HT3 Receptor

 

分子量

357.45

Formula

C20H27N3O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
WAY-100289
目录号:
HY-19136
需求量: