2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Bcl-2 Family
  4. WR-S-462

WR-S-462 是一种 STAT3 抑制剂。WR-S-462 在体外有效抑制 STAT3 的磷酸化及其生物学功能。WR-S-462 抑制 MDA-MB-231 细胞的 IC50 为 0.03 μM。WR-S-462 对 STAT3 蛋白表现出强结合亲和力，其 Kd 为 58 nM。WR-S-462 抑制 p-STAT3 的核转位，选择性抑制 MDA-MB-23 细胞中 p-STAT3Tyr705 的表达以及由 STAT3 调控的下游靶基因，如 Cyclin D1，Bcl-2 和 Bcl-xl 的表达。WR-S-462 抑制三阴性乳腺癌 (TNBC) 的生长和转移。

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WR-S-462 Chemical Structure

WR-S-462 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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WR-S-462 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

生物活性

WR-S-462 is a STAT3 inhibitor. WR-S-462 effectively suppresses STAT3 phosphorylation and biological functions in vitro. WR-S-462 inhibits MDA-MB-231 cells with an IC50 of 0.03 μM. WR-S-462 displays a strong binding affinity towards the STAT3 protein with a Kd of 58 nM. WR-S-462 inhibits the nuclear translocation of p-STAT3, selectively inhibits the expression of p-STAT3Tyr705 and downstream target genes regulated by STAT3 in MDA-MB-231 cells such as Cyclin D1, Bcl-2, and Bcl-xl. WR-S-462 inhibits TNBC (triple-negative breast cancer) growth and metastasis[1].

IC50 & Target[1]

STAT3

58 nM (Kd)

Bcl-2

 

BCLxL

 

分子量

462.52

Formula

C24H22N4O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

WR-S-462 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WR-S-462STATBcl-2 Familytriple-negative breast cancerphosphorylationgrowthmetastasisMDA-MB-231 cellsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-170946
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