2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. WRN inhibitor 10

WRN inhibitor 10 (Compound P24) 是 Werner 解旋酶 WRN 的抑制剂，IC50 为 1.1 nM。WRN inhibitor 10 抑制癌细胞 SW48 的增殖，IC50 为 39 nM。WRN inhibitor 10 表现出良好的肝微粒体稳定性和膜通透性。WRN inhibitor 10 在 CD-1 小鼠中表现出良好的药代动力学特征。

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WRN inhibitor 10 Chemical Structure

WRN inhibitor 10 Chemical Structure

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WRN inhibitor 10 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WRN inhibitor 10 (Compound P24) is an inhibitor for the Werner helicase WRN with an IC50 of 1.1 nM. WRN inhibitor 10 inhibits the proliferation of cancer cell SW48 with IC50 of 39 nM. WRN inhibitor 10 exhibits good liver microsomal stability and film permeability. WRN inhibitor 10 exhibits good pharmacokinetic characteristics in CD-1 mice[1].

分子量

755.04

Formula

C31H29BrClN9O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WRN inhibitor 10 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WRN inhibitor 10WRN inhibitor10WRN inhibitor-10DNA/RNA Synthesiscolorectal cancerSW48MSI-HHT-29CD-1 mouseInhibitorinhibitorinhibit

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