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Wy-45494 hydrochloride  (Synonyms: N-Desmethyl Venlafaxine hydrochloride; Wy 45494)

目录号: HY-131527
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摩尔计算器

Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) 是选择性去甲肾上腺素和血清素再摄取抑制剂 (SNRI) 文拉法辛的次要活性代谢物。它由文拉法辛通过细胞色素 P450 (CYP) 异构体 CYP3A4.2 形成。Wy-45494 hydrochloride 可抑制大鼠突触体制剂中的去甲肾上腺素和血清素再摄取（IC50s 分别为 4.7 和 1.6 μM）。在体内，Wy-45494 hydrochloride 可逆转小鼠利血平诱发的体温过低，最低有效剂量 (MED) 为 10 mg/kg。

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Wy-45494 hydrochloride Chemical Structure

Wy-45494 hydrochloride Chemical Structure

CAS No. : 93413-90-2

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Wy-45494 hydrochloride 相关抗体

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生物活性

Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.

分子量

299.84

Formula

C16H26ClNO2
CAS 号
中文名称

盐酸文拉法辛EP杂质D；1-[1-(4-甲氧基苯基)-2-(甲基氨基)乙基]环己醇盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Wy-45494 hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Wy-4549493413-90-2N-Desmethyl Venlafaxine Wy 45494盐酸文拉法辛EP杂质D1-[1-(4-甲氧基苯基)-2-(甲基氨基)乙基]环己醇盐酸盐Wy45494Wy 45494OthersInhibitorinhibitorinhibit

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