2. Apoptosis
  3. Apoptosis
  4. Xerophilusin B

Xerophilusin B 是一种从 Isodon xerophilus 中分离得到的抗癌剂，对食管鳞状细胞癌 (ESCC) 细胞系表现出抗增殖作用，可诱导 G2/M 细胞周期停滞，介导细胞凋亡 apoptosis。

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Xerophilusin B Chemical Structure

Xerophilusin B Chemical Structure

CAS No. : 167894-15-7

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Xerophilusin B 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Xerophilusin B, an anticancer agent isolated from Isodon xerophilus, exhibits antiproliferative effects on esophageal squamous cell carcinoma (ESCC) cell lines, induces G2/M cell cycle arrest, and mediates apoptosis[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
2 μM
Compound: 21
Cytotoxicity against human A549 cells after 48 hrs by MTT method
Cytotoxicity against human A549 cells after 48 hrs by MTT method
[PMID: 21534539]
HepG2 IC50
3.9 μM
Compound: 27
Cytotoxicity against human HepG2 cells after 48 hrs
Cytotoxicity against human HepG2 cells after 48 hrs
[PMID: 17665952]
HL-60 IC50
0.29 μg/mL
Compound: 2, xerophilusin B
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 10843567]
HL-60 IC50
0.8 μM
Compound: 21
Cytotoxicity against human HL60 cells after 48 hrs by MTT method
Cytotoxicity against human HL60 cells after 48 hrs by MTT method
[PMID: 21534539]
K562 IC50
0.73 μg/mL
Compound: 2, xerophilusin B
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
[PMID: 10843567]
K562 IC50
4.1 μM
Compound: 27
Cytotoxicity against human K562 cells after 48 hrs
Cytotoxicity against human K562 cells after 48 hrs
[PMID: 17665952]
MCF7 IC50
1.1 μM
Compound: 21
Cytotoxicity against human MCF7 cells after 48 hrs by MTT method
Cytotoxicity against human MCF7 cells after 48 hrs by MTT method
[PMID: 21534539]
MKN-28 IC50
0.17 μg/mL
Compound: 2, xerophilusin B
Cytotoxicity against human MKN28 cells after 48 hrs by MTT assay
Cytotoxicity against human MKN28 cells after 48 hrs by MTT assay
[PMID: 10843567]
MKN-45 IC50
0.4 μM
Compound: 27
Cytotoxicity against human MKN45 cells after 48 hrs
Cytotoxicity against human MKN45 cells after 48 hrs
[PMID: 17665952]
RAW264.7 IC50
0.225 μM
Compound: 2
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite accumulation after 24 hrs by Griess reagent method
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite accumulation after 24 hrs by Griess reagent method
[PMID: 19719246]
RAW264.7 IC50
0.7 μM
Compound: 2
Inhibition of NF-kappaB activation in LPS-stimulated mouse RAW264.7 cells assessed as relative luciferase activity after 24 hrs by dual reporter gene assay
Inhibition of NF-kappaB activation in LPS-stimulated mouse RAW264.7 cells assessed as relative luciferase activity after 24 hrs by dual reporter gene assay
[PMID: 19719246]
RAW264.7 IC50
10.1 μM
Compound: 2
Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay
[PMID: 19719246]
SMMC-7721 IC50
1.3 μM
Compound: 21
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT method
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT method
[PMID: 21534539]
SW480 IC50
0.9 μM
Compound: 21
Cytotoxicity against human SW480 cells after 48 hrs by MTT method
Cytotoxicity against human SW480 cells after 48 hrs by MTT method
[PMID: 21534539]
分子量

346.42

Formula

C20H26O5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Xerophilusin B 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xerophilusin B167894-15-7ApoptosisIsodon xerophilusESCCapoptosisInhibitorinhibitorinhibit

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