2. Stem Cell/Wnt Protein Tyrosine Kinase/RTK Apoptosis
  3. YAP TAM Receptor Survivin
  4. YAP/TAZ-TEAD-IN-2

YAP/TAZ-TEAD-IN-2 (Compound 51) 是一个抑制 YAP/TAZ 与 TEAD 之间相互作用的 YAP/TAZ-TEAD 抑制剂。YAP/TAZ-TEAD-IN-2 抑制 TEAD 的转录活性, 其 IC50 是 1.2 nM。YAP/TAZ-TEAD-IN-2 抑制 YAP/TAZ-TEAD 靶基因 (Cyr61, CTGF, AXL 和 Survivin) 表达和乳腺癌细胞增殖。

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YAP/TAZ-TEAD-IN-2 Chemical Structure

YAP/TAZ-TEAD-IN-2 Chemical Structure

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YAP/TAZ-TEAD-IN-2 相关抗体

Top Publications Citing Use of Products

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Axl Mer Tyro3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that inhibits the interaction between YAP/TAZ and TEAD. YAP/TAZ-TEAD-IN-2 suppresses the transcriptional activity of TEAD, with an IC50 of 1.2 nM. YAP/TAZ-TEAD-IN-2 inhibits YAP/TAZ-TEAD target genes expression (Cyr61, CTGF, AXL and Survivin) and breast cancer cell proliferation[1].

体外研究
(In Vitro)

YAP/TAZ-TEAD-IN-2 (2.5-20 μM, 72 h) 剂量依赖性抑制 MDA-MB-231 细胞增殖，其 IC50 为 4.4 μM[1]。
YAP/TAZ-TEAD-IN-2 (1-10 μM, 48 h) 抑制 MDA-MB-231 细胞中四种主要 YAP/TAZ-TEAD 靶蛋白，即 Cyr61、CTGF、AXL 和 BIRC5 (Survivin) 表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

YAP/TAZ-TEAD-IN-2 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231 cells
Concentration: 2.5, 5, 10, 20 μM
Incubation Time: 72 h
Result: Dose-dependently inhibited MDA-MB-231 cells proliferation with IC50 of 4.4 μM.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231 cells
Concentration: 1, 5, 10 μM
Incubation Time: 48 h
Result: Dose-dependently inhibited the four principal YAP/TAZ-TEAD target proteins, namely Cyr61, CTGF, AXL and BIRC5 (Survivin).
分子量

356.44

Formula

C19H20N2O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YAP/TAZ-TEAD-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YAP/TAZ-TEAD-IN-2YAPTAM ReceptorSurvivinYes-associated proteinTyro3AxlMerBreast cancerProliferationMDA-MB-231 cellsHippoCyr61Inhibitorinhibitorinhibit

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