2. Membrane Transporter/Ion Channel
  3. SGLT
  4. YM543 free base

YM543 free base 是一种口服有效的钠-葡萄糖协同转运蛋白 (SGLT) 2 抑制剂。YM543 free base 降低血糖水平。YM543 free base 可用于糖尿病研究。

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YM543 free base Chemical Structure

YM543 free base Chemical Structure

CAS No. : 655237-16-4

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YM543 free base 相关抗体

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SGLT1 SGLT2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YM543 free base is a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor. YM543 free base reduces blood glucose levels. YM543 free base can be used in research of diabetes[1][2].

IC50 & Target[1]

SGLT2

 

体内研究
(In Vivo)

YM543 free base (0-3 mg/kg; p.o.) 在 KK/Ay 2 型糖尿病小鼠中降低血糖水平并改善葡萄糖耐量，同时增加尿糖排泄，效果甚至在 12 小时后仍持续[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: KK/Ay 2 diabetic mice[1]
Dosage: 0.1, 0.3, 1, and 3 mg/kg
Administration: oral administration
Result: Had a strong and sustained antihyperglycemic effect in both KK/Ay type 2 diabetic mice.
Animal Model: Male Sprague–Dawley rats[1]
Dosage: 1.0 and 3.0 mg/kg
Administration: intravenous injection (1.0 mg/kg) and oral administration (3.0 mg/kg)
Result: 1.19
Administration iv (1 mg/kg) po (3 mg/kg)
T1/2 (h) 0.9 1.3
CLtot (L/h/kg) 2483
Vdss (L/kg) 3360
Cmax (ng/mL) 101
Tmax (h) 0.5
AUC0-inf (ng h/mL) 403
F % 29
Clinical Trial
分子量

396.43

Formula

C23H24O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YM543 free base 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YM543655237-16-4YM 543YM-543SGLTSodium-dependent glucose cotransportersblood glucosediabetesurinary glucose excretiondiabetic miceInhibitorinhibitorinhibit

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HY-122613
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