1. Metabolic Enzyme/Protease
  2. Proteasome
  3. YSY01A

YSY01A 是一种 Proteasome 抑制剂, 可以通过通过诱导细胞凋亡 (Apoptosis) 来抑制癌细胞存活,对HEK293T、 A549 、MCF-7、 MGC-803 、PC-3M 细胞的 IC50 分别为 51.0 1、9.2 1、5.2 1、8.9 、35.4 nM。同时 YSY01A 也是 gp130JAK2 降解剂,可通过下调人 A549 肺癌细胞中的 gp130JAK2 来消除组成型 STAT3 信号传导。YSY01A 有望用于在抗癌领域研究。

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YSY01A Chemical Structure

YSY01A Chemical Structure

CAS No. : 1194235-46-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YSY01A is a proteasome inhibitor that can suppress cancer cell survival by inducing apoptosis (Apoptosis). Its IC50 values are 51.0 nM for HEK293T, 9.2 nM for A549, 5.2 nM for MCF-7, 8.9 nM for MGC-803, and 35.4 nM for PC-3M cells. Additionally, YSY01A is also a degrader of gp130 and JAK2, and it eliminates constitutive STAT3 signaling by downregulating gp130 and JAK2 in human A549 lung cancer cells. YSY01A holds promise for research in the field of cancer therapy[1].

分子量

547.45

Formula

C29H38BN5O5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
YSY01A
目录号:
HY-162885
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