2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. YZL-51N

YZL-51N 是一种选择性 SIRT7 抑制剂，IC50 值为 12.71 μM。YZL-51N 通过占领 NAD+ 结合袋来破坏 SIRT7 酶的活性，减弱 DNA 损伤修复，抑制癌细胞存活。YZL-51N 具有抗肿瘤活性，可用于癌症领域研究。

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YZL-51N Chemical Structure

YZL-51N Chemical Structure

CAS No. : 3031072-69-9

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YZL-51N 相关抗体

Top Publications Citing Use of Products

查看 Sirtuin 亚型特异性产品:

查看所有亚型
Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YZL-51N is a selective SIRT7 inhibitor with IC50 value of 12.71 μM. YZL-51N disrupts SIRT7 enzyme activity by occupying the NAD+ binding pocket, thereby weakening DNA damage repair and inhibiting cancer cell survival. YZL-51N possesses anti-tumor activity and can be used in cancer research[1].

IC50 & Target

SIRT7

12.71 μM (IC50)

体外研究
(In Vitro)

YZL-51N (0-40 μM, 8 h) 在 HCT116 和 HT29 细胞中呈剂量依赖性的增加 H3K18ac 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

YZL-51N 相关抗体:

Cell Viability Assay[1]

Cell Line: HCT116, HT29 and SW620
Concentration: 0-160 μM
Incubation Time: 48 h
Result: Decreased cell proliferation in three colorectal cancer cell lines.
体内研究
(In Vivo)

YZL-51N (15 mg/kg, 皮下注射) 在 HCT116 异种移植模型中可使肿瘤体积减小[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

330.29

Formula

C17H14O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YZL-51N 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YZL-51N3031072-69-9SirtuinSIRT7 cellsHCT116 cellsHT29 cellsHCT116 xenograft mice modelAnticancer activityInhibitorinhibitorinhibit

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产品名称：
YZL-51N
目录号：
HY-159124
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