1. Inhibitory Antibodies
  2. Zanolimumab

Zanolimumab  (Synonyms: 扎木单抗; Anti-Human CD4 Recombinant Antibody)

目录号: HY-P99266 纯度: 99.21%
COA

Zanolimumab (Anti-Human CD4 Recombinant Antibody) 是一种人单克隆抗体,靶向 CD4。Zanolimumab 可有效抑制 T 细胞受体 (TCR) 的信号转导。Zanolimumab 可用于类风湿性关节炎、银屑病、黑色素瘤、皮肤和周围 T 细胞淋巴瘤的研究。

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CAS No. : 652153-01-0

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规格 价格 是否有货 数量
1 mg ¥3000
In-stock
5 mg ¥7500
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Zanolimumab (Anti-Human CD4 Recombinant Antibody) is a fully human monoclonal antibody targets CD4. Zanolimumab effectively inhibits T-cell receptor (TCR) signal transduction. Zanolimumab can be used for the research of heumatoid arthritis, psoriasis, melanoma, cutaneous and peripheral T-cell lymphoma[1].

同型

Human IgG1 kappa

推荐同型对照抗体
种属

Human

体外研究
(In Vitro)

Zanolimumab (10 and 100 ng/mL) shows strong killing of the CD4+ T cells with a better effect to CD45RO+ subset than the CD45RA+ subset[1].
Zanolimumab (1-10000 ng/mL) Fc and dose-dependently down-regulates the level of CD4 from purified primary CD4+ T cells and SUP-T1 T cells[1].
Zanolimumab (1-10000 ng/mL) potently inhibits of TCR-stimulated T-cell proliferation both in tetanus toxin induced and anti-CD3 induced T-cell proliferation[1].
Zanolimumab (0-30 min) inhibits TCR signal transduction[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

扎木单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Zanolimumab
目录号:
HY-P99266
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