2. Protein Tyrosine Kinase/RTK
  3. DYRK
  4. ZJCK-6-46

ZJCK-6-46 (32) 是潜在的具有口服活性的 DYRK1A 抑制剂 (IC50 = 0.68 nM)，具有良好的CNC通透性。ZJCK-6-46 (32) 可下调 tau 磷酸化。ZJCK-6-46 (32) 通过明显减少磷酸化tau蛋白的表达和神经元的丢失来改善认知功能障碍。

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ZJCK-6-46 Chemical Structure

ZJCK-6-46 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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ZJCK-6-46 相关抗体

Top Publications Citing Use of Products

查看 DYRK 亚型特异性产品:

查看所有亚型
DYRK1 DYRK2 DYRK3 DYRK4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZJCK-6-46 (32) is a potential and orally activeDYRK1A inhibitor (IC50 = 0.68 nM) with high BBB permeability (CNS+). ZJCK-6-46 (32) reduces tau phosphorylation. ZJCK-6-46 (32) ameliorates cognitive dysfunction by obviously reducing the expression of phosphorylated tau and neuronal loss in vivo[1].

IC50 & Target[1]

DYRK1A

0.68 nM (IC50)

DYRK1B

1.02 nM (IC50)

DYRK2

14.18 nM (IC50)

DYRK3

17.48 nM (IC50)

DYRK4

401.3 nM (IC50)

CLK1

1.68 nM (IC50)

CLK3

38.91 nM (IC50)

CLK4

1.80 nM (IC50)

体内研究
(In Vivo)

ZJCK-6-46 (32, 20-30 mg/kg, orally, OA-induced (MOD) mice) 显著下调OA (Okadaic acid, HY-N6785) 诱导小鼠的 CA1 区和 DG 区p-Tau thr212 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

395.46

Formula

C24H21N5O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZJCK-6-46 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZJCK-6-46DYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-162750
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