α-CGRP (mouse, rat) (TFA)  (Synonyms: CGRP (83-119), mouse, rat TFA)

α-CGRP (mouse, rat) TFA, a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) TFA can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) TFA has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies^[1][2][3][4].

α-CGRP (mouse, rat) TFA 可调节 2 组先天淋巴样细胞反应^[1]。
α-CGRP (mouse, rat) TFA 可调节胰岛素分泌，降低 2 型糖尿病的风险^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

α-CGRP (mouse, rat) TFA (0.25, 0.5, 1 μg/kg/min, 静脉注射) 剂量依赖性地降低了平均动脉血压，同时心率和全身血管传导增加，而心输出量保持不变^[3]。
α-CGRP (mouse, rat) TFA 在 Kainic acid (KA) 诱导的海马 CA3 区锥体细胞死亡的调控中发挥重要作用^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3920.27

C₁₆₂H₂₆₂N₅₀O₅₂S₂.C₂HF₃O₂

固体

White to off-white

SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2 (Disulfide bridge:Cys2-Cys7)

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

• [1]. Whitby K, et al. Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo. J Virol. 2005 Jul;79(14):8698-706.  [Content Brief]

  [2]. Xu H, et al. Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses. Immunity. 2019 Oct 15;51(4):696-708.e9.  [Content Brief]

  [3]. Arulmani U, et al. Effects of the calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS on alpha-CGRP-induced regional haemodynamic changes in anaesthetised rats. Basic Clin Pharmacol Toxicol. 2004 Jun;94(6):291-7.  [Content Brief]

  [4]. Park SH, et al. Role of α-CGRP in the regulation of neurotoxic responses induced by kainic acid in mice. Peptides. 2013 Jun;44:158-62.  [Content Brief]