2. Metabolic Enzyme/Protease
  3. Glucosidase
  4. α-Glucosidase-IN-57

α-Glucosidase-IN-57 (Compound 10c) 是一种具有竞争性和口服活性的 α-glucosidase 抑制剂， IC50 值为 0.180 μM，Ki 为 0.15 μM。α-Glucosidase-IN-57 能降低小鼠空腹和总体血糖水平，可用于抗糖尿病的研究。

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α-Glucosidase-IN-57 Chemical Structure

α-Glucosidase-IN-57 Chemical Structure

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α-Glucosidase-IN-57 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

α-Glucosidase-IN-57 (Compound 10c) is a competitive and orally active α-glucosidase inhibitor with an IC50 value of 0.180 μM and a Ki of 0.15 μM. α-Glucosidase-IN-57 can reduce fasting and overall blood glucose levels in mice, and can be used for anti-diabetes research[1].

体外研究
(In Vitro)

α-Glucosidase-IN-57 (Compound 10c) (0, 0.045, 0.09, 0.18 μM) 与底物 p-NPG (HY-W039892) (1-16 μM) 竞争同一个 α-葡萄糖苷酶的活性位点，是一种强效的竞争性 α-glucosidase 抑制剂[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

α-Glucosidase-IN-57 相关抗体:
体内研究
(In Vivo)

α-Glucosidase-IN-57 (Compound 10c) (250, 500, 1000 mg/kg; 口服; 72 小时) 在 Wistar albino 大鼠模型中表现出良好的耐受性和安全性[1]。
α-Glucosidase-IN-57 (10, 25, 50 mg/kg; 口服; 每天一次，共 28 天) 在糖尿病的 Wistar albino 大鼠模型中具有降糖活性，包括降低空腹血糖水平，改善葡萄糖耐量，并可能改善胰腺组织的胰岛结构[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar albino rats with diabetes[1]
Dosage: α-Glucosidase-IN-57: 10, 25, 50 mg/kg; Acarbose: 50 mg/kg
Administration: Oral gavage (p.o.); once daily for 28 days
Result: In the first 7 days, fasting blood glucose levels were not significantly different from diabetic controls.
On day 14, significantly reduced blood glucose levels at oral doses of 25 and 50 mg/kg, while Acarbose (at oral doses of 50 mg/kg) achieved the same effect.
On day 21, had the best hypoglycemic effect with acarbose at oral doses of 25 and 50 mg/kg, which was significantly better than the diabetic control group.
On day 28, blood glucose levels were significantly lower than those in the diabetic control group.
分子量

530.61

Formula

C32H23FN4OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

α-Glucosidase-IN-57 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Glucosidase-IN-57GlucosidaseAnti-diabetic2-(quinoline-2-ylthio)acetamidType 2 diabetes mellitusInhibitorinhibitorinhibit

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目录号：
HY-163433
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