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  3. α4 integrin receptor antagonist 3

α4 integrin receptor antagonist 3 

目录号: HY-159179
产品使用指南

α4 integrin receptor antagonist 3 (Compound 11) 是一种具有口服活性的 α4 整合素受体 (α4 integrin receptor) 拮抗剂。α4 integrin receptor antagonist 3 可以抑制 α4β1/VCAM-1α4β7/MAdCAM-1 相互作用介导的 K562 细胞粘附,IC50 值分别为 130 nM 和 2 nM。α4 integrin receptor antagonist 3 具有用于葡聚糖硫酸钠 (DSS) 结肠炎小鼠模型研究的潜力。

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α4 integrin receptor antagonist 3 Chemical Structure

α4 integrin receptor antagonist 3 Chemical Structure

CAS No. : 863226-74-8

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

α4 integrin receptor antagonist 3 (Compound 11) is an orally active α4integrin receptor antagonist. α4 integrin receptor antagonist 3 can inhibit the adhesion of K562 cells mediated by the interaction between α4β1/VCAM-1 and α4β7/MAdCAM-1, with IC50 values of 130 nM and 2 nM, respectively. α4 integrin receptor antagonist 3 has the potential to be used in the study of dextran sulfate sodium (DSS) colitis mouse model[1].

IC50 & Target

α4β1

 

α4β7

 

体外研究
(In Vitro)

α4 integrin receptor antagonist 3 可以抑制 α4β1/VCAM-1和 α4β7/MAdCAM-1 相互作用介导的 K562 细胞粘附[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

506.34

Formula

C23H21Cl2N3O6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

α4 integrin receptor antagonist 3 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
α4 integrin receptor antagonist 3
目录号:
HY-159179
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