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  4. δ-Tocotrienol prodrug-1

δ-Tocotrienol prodrug-1 (compound 5b) 是 δ-生育三烯酚 (HY-122778) 的前药。δ-Tocotrienol prodrug-1 具有放射保护功效。δ-Tocotrienol prodrug-1 促进小鼠骨髓和脾脏中的造血祖细胞和干细胞再生。

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δ-Tocotrienol prodrug-1 Chemical Structure

δ-Tocotrienol prodrug-1 Chemical Structure

CAS No. : 128254-90-0

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δ-Tocotrienol prodrug-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

δ-Tocotrienol prodrug-1 (compound 5b) is a prodrug of δ-tocotrienol (HY-122778). δ-Tocotrienol prodrug-1 shows radioprotective efficacy. δ-Tocotrienol prodrug-1 promotes the hematopoietic progenitor and stem cell regeneration in murine bone marrow and spleen[1].

体内研究
(In Vivo)

δ-Tocotrienol prodrug-1 (compound 5b) (100 mg/kg; s.c. once) 在小鼠中显示 30 天内存活率为 90%[1]。
药代动力学参数[1]。

Parameters 100 mg/kg (i.v./DT3) 100 mg/kg (s.c./DT3)
tmax (h) 0.083 0.67
Cmax (ng/ml) 5.15 × 105 2.02 × 103
t1/2 (h) 10.40 26.76
AUC(0-t) (h ng/mL) 1.96×105 0.27×105
AUC(0-∞) (h ng/ mL) 2.06×105 0.54×105
CL (mL/h/kg) 225.32 -
MRT(0-t) (h) 1.36 11.89
MRT(0-∞) (h) 3.47 38.38
V(dss) (mL/kg) 336.58 -
F % - 13.86

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 21-24 g C57BL/6J male mice[1]
Dosage: 100 mg/kg
Administration: S.c.;once; 24 h prior to 8.5 Gy or 9.5 Gy total-body irradiation (TBI)
Result: showed 90 % survival rate at 30 days in mice.
分子量

496.68

Formula

C31H44O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

δ-Tocotrienol prodrug-1 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

δ-Tocotrienol prodrug-1128254-90-0Othersradioprotective efficacy9.5 Gyhematopoietic progenitorstem cellInhibitorinhibitorinhibit

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