2. Metabolic Enzyme/Protease
  3. Glucosidase
  4. α-Glucosidase-IN-21

α-Glucosidase-IN-21 (Compound 2B) 是一种口服有效的 α-glucosidase 抑制剂，其 IC50 为 2.62 μM。α-Glucosidase-IN-21 具有抗糖尿病活性。

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α-Glucosidase-IN-21 Chemical Structure

α-Glucosidase-IN-21 Chemical Structure

CAS No. : 321686-01-5

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α-Glucosidase-IN-21 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

α-Glucosidase-IN-21 (Compound 2B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 2.62 μM. α-Glucosidase-IN-21 shows anti-diabetic activity[1].

体内研究
(In Vivo)

α-Glucosidase-IN-21 (Compound 2B; 10 and 20 mg/kg; p.o.; daily, for 4 weeks) has anti-diabetic activity in Streptozocin (HY-13753)-induced diabetic rats[1].
α-Glucosidase-IN-21 (10 and 20 mg/kg; p.o.; once) significantly decreases the serum glucose level after the administration of glucose (3 g/kg, oral) in rats[1].
α-Glucosidase-IN-21 (2000 mg/kg; p.o.; daily, for 2 weeks) demonstrates no mortality in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar albino rats (170-200 g), Streptozotocin-induced diabetes model[1]
Dosage: 10 and 20 mg/kg
Administration: Oral administration; daily, for 4 weeks
Result: Decreased the level of blood glucose, reversed Streptozocin-induced body weight loss. Showed antihyperlipidemic effects on Streptozotocin-induced diabetes, reduced to a significant level of serum biomarkers.
分子量

389.51

Formula

C24H23NO2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

α-Glucosidase-IN-21 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Glucosidase-IN-21321686-01-5Glucosidaseanti-diabeticblood glucoseanti-hyperlipidemicdiabetesInhibitorinhibitorinhibit

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目录号：
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