1,4-PBIT dihydrobromide (Synonyms: 1,4-PB-ITU dihydrobromide)

目录号: HY-135224: FAQs
Data Sheet 产品使用指南

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1,4-PBIT (1,4-PB-ITU) dihydrobromide (compound 46) 是一种有效的一氧化氮合酶 (NOS) 抑制剂，对诱导型 (iNOS)，内皮 (eNOS) 和神经元 (nNOS) 同工酶的 K_i 值分别为 7.6 nM、360 nM 和 16 nM。

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1,4-PBIT dihydrobromide Chemical Structure

CAS No. : 157254-60-9

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规格	价格	是否有货
5 mg	￥219	3 - 4 周
10 mg	￥346	3 - 4 周
50 mg		询价
100 mg		询价

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nNOS iNOS eNOS

生物活性
纯度 & 产品资料
参考文献

生物活性

1,4-PBIT (1,4-PB-ITU) dihydrobromide (compound 46) is a potent nitric oxide synthases (NOS) inhibitor, with K_i values of 7.6 nM, 360 nM, and 16 nM for the inducible (iNOS), endothelial (eNOS), and neuronal (nNOS) isozymes, respectively^[1].

IC₅₀ & Target^[1]

iNOS

7.6 nM (Ki)

eNOS

360 nM (Ki)

nNOS

16 nM (Ki)

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 100 μM Compound: 1, PBIT	Antitumor activity against human A549 cells after 24 hrs by MTS assay Antitumor activity against human A549 cells after 24 hrs by MTS assay	[PMID: 20153642]
Caco-2	IC₅₀	59.4 μM Compound: 1, PBIT	Antitumor activity against human Caco-2 cells after 72 hrs by MTS assay Antitumor activity against human Caco-2 cells after 72 hrs by MTS assay	[PMID: 20153642]
HCT-116	IC₅₀	> 100 μM Compound: 1, PBIT	Antitumor activity against human HCT116 cells after 72 hrs by MTS assay Antitumor activity against human HCT116 cells after 72 hrs by MTS assay	[PMID: 20153642]
HT-1080	IC₅₀	> 100 μM Compound: 1, PBIT	Antitumor activity against human HT1080 cells after 24 hrs by MTS assay Antitumor activity against human HT1080 cells after 24 hrs by MTS assay	[PMID: 20153642]
HT-29	IC₅₀	2.4 μM Compound: 1, PBIT	Antitumor activity against human HT-29 cells after 72 hrs by MTS assay Antitumor activity against human HT-29 cells after 72 hrs by MTS assay	[PMID: 20153642]
MDA-MB-231	IC₅₀	> 100 μM Compound: 1, PBIT	Antitumor activity against human MDA-MB-231 cells after 24 hrs by MTS assay Antitumor activity against human MDA-MB-231 cells after 24 hrs by MTS assay	[PMID: 20153642]
OVCAR-3	IC₅₀	> 100 μM Compound: 1, PBIT	Antitumor activity against human OVCAR-3 cells after 24 hrs by MTS assay Antitumor activity against human OVCAR-3 cells after 24 hrs by MTS assay	[PMID: 20153642]
PC-3	IC₅₀	100 μM Compound: 1, PBIT	Antitumor activity against human PC3 cells after 24 hrs by MTS assay Antitumor activity against human PC3 cells after 24 hrs by MTS assay	[PMID: 20153642]
SW480	IC₅₀	16 μM Compound: 1, PBIT	Antitumor activity against human SW480 cells after 72 hrs by MTS assay Antitumor activity against human SW480 cells after 72 hrs by MTS assay	[PMID: 20153642]
WM-115	IC₅₀	> 100 μM Compound: 1, PBIT	Antitumor activity against human WM115 cells after 24 hrs by MTS assay Antitumor activity against human WM115 cells after 24 hrs by MTS assay	[PMID: 20153642]

分子量

444.25

Formula

C₁₂H₂₀Br₂N₄S₂

CAS 号

157254-60-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. E P Garvey, et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J Biol Chem. 1994 Oct 28;269(43):26669-76. [Content Brief]

1,4-PBIT dihydrobromide 相关分类

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,4-PBIT dihydrobromide157254-60-91,4-PB-ITU dihydrobromideNO SynthaseNitric oxide synthasesNOSNOS InhibitoreNOSnNOSiNOSInhibitorinhibitorinhibit

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

1,4-PBIT dihydrobromide (Synonyms: 1,4-PB-ITU dihydrobromide)

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1,4-PBIT dihydrobromide (Synonyms: 1,4-PB-ITU dihydrobromide)

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