10-Undecenoic acid zinc salt  (Synonyms: 十一烯酸锌; Zinc undecylenate)

10-Undecenoic acid zinc salt (Undecylenic acid zinc salt) is an antifungal agent. 10-Undecenoic acid zinc salt inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid zinc salt has neuroprotective effects. 10-Undecenoic acid zinc salt has anticancer effects on a variety of tumors. 10-Undecenoic acid zinc salt inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid zinc salt inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa^{[1][2][3][4][5][6][7][8]}.

10-Undecenoic acid zinc salt 与 L-精氨酸复合的制剂 (1.6-3.8 mM；3-6 h) 可诱导肿瘤细胞 (A549 和 Jurkat) 凋亡^[2]。
10-Undecenoic acid zinc salt (24 h) 对人类肿瘤细胞系 HeLa、A549、Jurkat 和 U937 表现出剂量依赖性细胞毒性，IC₅₀ 分别为 0.9862、0.3751、0.5782、0.2893 mM^[2]。
10-Undecenoic acid zinc salt (高达 5 μM) 可显著增加碱性磷酸酶和钙沉积的表达和活性，并诱导小鼠成骨细胞 MC3T3-E1 subclone 4 和原代小鼠颅骨细胞中骨钙素基因的表达^[3]。
10-Undecenoic acid zinc salt 减少了 C. albicans 生物膜中的活细胞和活性细胞数量并使生物膜变薄，同时增加了 C. glabrata 生物膜中的细胞数量、代谢活性和蛋白酶活性^[4]。
10-Undecenoic acid zinc salt (20 μM) 对 SH-SY5Y 细胞中谷氨酸、H₂O₂ 和 Aβ_1-42 诱导的细胞死亡具有神经保护作用^[5]。
10-Undecenoic acid zinc salt (1-40 mM；6-24 h) 可减少 H₂O₂、Staurosporine (HY-15141) 和 Ddoxorubicin (HY-15142A) 诱导的 SH-SY5Y 细胞死亡^[6]。
10-Undecenoic acid zinc salt (12.5-50 μg/mL) 导致枯草芽孢杆菌中的 LuxS/AI-2QS 系统减少，(15.625-250 μg/mL) 导致铜绿假单胞菌中的 LasI/LasR QS 系统降低 10-54%^[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

10-Undecenoic acid zinc salt (arginine undecylenate (GS-1) 形式，157.6 mg/mL；局部给药；每天两次；6 天) 可有效清除 MRSA 皮肤感染大鼠模型中表皮和真皮层中的 MRSA 感染^[8]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

431.91

C₂₂H₃₈O₄Zn

557-08-4

固体

White to off-white

十一烯酸锌

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Brayden DJ, et al. Efficacious intestinal permeation enhancement induced by the sodium salt of 10-undecylenic acid, a medium chain fatty acid derivative. AAPS J. 2014 Sep;16(5):1064-76.  [Content Brief]

  [2]. Day ZI, et al. Novel Formulation of Undecylenic Acid induces Tumor Cell Apoptosis. Int J Mol Sci. 2022 Nov 16;23(22):14170.  [Content Brief]

  [3]. Kim MH, et al. Stimulatory effect of undecylenic acid on mouse osteoblast differentiation. Phytother Res. 2010 Apr;24(4):559-64.  [Content Brief]

  [4]. Gonçalves LM, et al. Effects of undecylenic acid released from denture liner on Candida biofilms. J Dent Res. 2012 Oct;91(10):985-9.  [Content Brief]

  [5]. Lee E, et al. Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of μ-calpain. Eur J Pharm Sci. 2012 May 12;46(1-2):17-25.  [Content Brief]

  [6]. Jantas D, et al. An Involvement of PI3-K/Akt Activation and Inhibition of AIF Translocation in Neuroprotective Effects of Undecylenic Acid (UDA) Against Pro-Apoptotic Factors-Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells. J Cell Biochem. 2015 Dec;116(12):2882-95.  [Content Brief]

  [7]. Fernandes S, et al. Curcumin and 10-Undecenoic acid zinc salt as natural quorum sensing inhibitors of LuxS/AI-2 of Bacillus subtilis and LasI/LasR of Pseudomonas aeruginosa. Food Res Int. 2023 Mar;165:112519.  [Content Brief]

  [8]. Mayfosh A, et al. A Novel Ammonium Carboxylate Salt of Undecylenic Acid for the Topical Treatment of Gram-Positive and Antibiotic-Resistant Skin Infections. Exp Dermatol. 2025 Mar;34(3):e70075.  [Content Brief]