2. GPCR/G Protein
  3. Leukotriene Receptor
  4. 14,15-Dehydro Leukotriene B4

14,15-Dehydro Leukotriene B4 (Compound 4) 是一种 LTB4 receptor 拮抗剂。14,15-Dehydro Leukotriene B4 对 BLT1 具有较高的结合亲和力， Ki 值为 27 nM，对 BLT2 的 Ki 值为 473 nM。14,15-Dehydro Leukotriene B4 抑制 LTB4 诱导的大鼠多态核白细胞溶菌酶释放，IC50 值为 1 µM。

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14,15-Dehydro Leukotriene B4 Chemical Structure

14,15-Dehydro Leukotriene B4 Chemical Structure

CAS No. : 114616-11-4

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14,15-Dehydro Leukotriene B4 相关抗体

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查看 Leukotriene Receptor 亚型特异性产品:

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LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

  • 生物活性

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生物活性

14,15-Dehydro Leukotriene B4 (Compound 4) is a LTB4 receptor antagonist. 14,15-Dehydro Leukotriene B4 also has a higher binding affinity for BLT1 with a Ki value of 27 nM and BLT2 with a Ki value of 473 nM. 14,15-Dehydro Leukotriene B4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM[1][2].

IC50 & Target

BLT1

27 nM (Ki)

BLT2

473 nM (Ki)

分子量

334.45

Formula

C20H30O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

14,15-Dehydro Leukotriene B4 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

14,15-Dehydro Leukotriene B4114616-11-4Leukotriene ReceptorLTB4 receptorBLT1BLT2lysozymespolymorphonuclear leukoctyesInhibitorinhibitorinhibit

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