2. NF-κB Metabolic Enzyme/Protease Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor
  3. NF-κB PPAR
  4. 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid

17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid  (Synonyms: 17-Oxo-DPA; 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA)

目录号: HY-116115
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17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid (17-Oxo-DPA; 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA) 是 Docosahexaenoic acid (DHA) (HY-B2167) 的亲电氧代衍生物 (EFOX)。17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid 在炎症过程中由活化巨噬细胞中的 COX-2 催化机制产生。17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid 是 PPARγ 的激动剂和 NF-κB 信号通路的调节剂，可抑制促炎细胞因子和一氧化氮的产生，并表现出抗炎活性。

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17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid Chemical Structure

17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid Chemical Structure

CAS No. : 1233715-33-7

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17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid (17-Oxo-DPA; 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA) is an electrophilic oxo-derivative (EFOX) of the docosahexaenoic acid (DHA) (HY-B2167). 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is generated during inflammation by COX-2-catalyzed mechanism in activated macrophages. 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid acts as an agonist for PPARγ and a modulator for NF-κB signaling pathway, inhibits the production of pro-inflammatory cytokines and nitric oxide, and exhibits anti-inflammatory efficacy[1].

IC50 & Target

PPARγ

 

分子量

344.49

Formula

C22H32O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid1233715-33-717-Oxo-DPA 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPANF-κBPPARNuclear factor-κBNuclear factor-kappaBPeroxisome proliferator-activated receptorsanti-inflammatoryelectrophilic oxo-derivativeEFOXInhibitorinhibitorinhibit

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