2-Desoxy-4-epi-pulchellin

目录号: HY-N1725 纯度: 99.76%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

2-Desoxy-4-epi-pulchellin (compound 13) 是从 Polygonum hydropiper 的二氯甲烷可溶部分中分离得到的化合物。

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2-Desoxy-4-epi-pulchellin Chemical Structure

CAS No. : 122872-03-1

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规格	价格	是否有货
1 mg	￥750	In-stock
5 mg	￥1800	In-stock
10 mg		询价
50 mg		询价

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生物活性
纯度 & 产品资料
参考文献

生物活性

2-Desoxy-4-epi-pulchellin (compound 13) is a compound isolated from dichloromethane-soluble portion of Polygonum hydropiper^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	6.2 μM Compound: 4	Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
DU-145	IC₅₀	3.1 μM Compound: 4	Cytotoxicity against human DU145 cells after 72 hrs by CCK8 assay Cytotoxicity against human DU145 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
HCT-116	IC₅₀	4.43 μM Compound: 1; PCL	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30711391]
HeLa	IC₅₀	6 μM Compound: 4	Cytotoxicity against human HeLa cells after 72 hrs by CCK8 assay Cytotoxicity against human HeLa cells after 72 hrs by CCK8 assay	[PMID: 26316467]
HL-60	IC₅₀	2.4 μM Compound: 4	Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
HT-29	IC₅₀	3.37 μM Compound: 1; PCL	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30711391]
K562	IC₅₀	17 μM Compound: 4	Cytotoxicity against human K562 cells after 72 hrs by CCK8 assay Cytotoxicity against human K562 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
MCF7	IC₅₀	11 μM Compound: 4	Cytotoxicity against human MCF7 cells after 72 hrs by CCK8 assay Cytotoxicity against human MCF7 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
MCF7	IC₅₀	9.8 μg/mL Compound: 9, pseudoguaianolide	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21109433]
MDCK	IC₅₀	29.3 μM Compound: 4	Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining	[PMID: 26316467]
MDCK	IC₅₀	47.3 μM Compound: 4	Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining	[PMID: 26316467]
MOLT-4	IC₅₀	5.5 μM Compound: 4	Cytotoxicity against human MOLT4 cells after 72 hrs by CCK8 assay Cytotoxicity against human MOLT4 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
NCI-H1975	IC₅₀	13 μM Compound: 4	Cytotoxicity against human NCI-H1975 cells after 72 hrs by CCK8 assay Cytotoxicity against human NCI-H1975 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
Neutrophil	IC₅₀	> 10 μg/mL Compound: 5	Inhibition of FMLP/CB-induced elastase release in human neutrophils after 5 mins by spectrophotometry Inhibition of FMLP/CB-induced elastase release in human neutrophils after 5 mins by spectrophotometry	[PMID: 24997688]
Neutrophil	IC₅₀	> 10 μg/mL Compound: 5	Inhibition of FMLP/CB-induced superoxide anion generation in human neutrophils by ferricytochrome c reduction method Inhibition of FMLP/CB-induced superoxide anion generation in human neutrophils by ferricytochrome c reduction method	[PMID: 24997688]
RAW264.7	IC₅₀	0.1 μM Compound: 14	Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs	[PMID: 20515062]
RAW264.7	IC₅₀	14.9 μM Compound: 5	Inhibition of NO production in LPS/IFN-gamma activated mouse RAW264.7 cells after 24 hrs by Griess assay Inhibition of NO production in LPS/IFN-gamma activated mouse RAW264.7 cells after 24 hrs by Griess assay	[PMID: 24997688]
RAW264.7	IC₅₀	2.5 μM Compound: 15	Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay	[PMID: 27276091]
RAW264.7	IC₅₀	9.89 μM Compound: 19	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method	[PMID: 21924800]
SGC-7901	IC₅₀	22 μM Compound: 4	Cytotoxicity against human SGC7901 cells after 72 hrs by CCK8 assay Cytotoxicity against human SGC7901 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
U-937	IC₅₀	2.2 μM Compound: 4	Cytotoxicity against human U937 cells after 72 hrs by CCK8 assay Cytotoxicity against human U937 cells after 72 hrs by CCK8 assay	[PMID: 26316467]

分子量

250.33

Formula

C₁₅H₂₂O₃

CAS 号

122872-03-1

性状

固体

颜色

White to off-white

结构分类

Others

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

细胞实验：

DMSO 中的溶解度 : 25 mg/mL (99.87 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.9947 mL	19.9736 mL	39.9473 mL
5 mM	0.7989 mL	3.9947 mL	7.9895 mL
10 mM	0.3995 mL	1.9974 mL	3.9947 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.76%

选择批次：

Data Sheet (598 KB) SDS (252 KB)

COA (179 KB) HNMR (226 KB) RP-HPLC (256 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Xiao H, et al. Biological evaluation of phytoconstituents from Polygonum hydropiper. Nat Prod Res. 2017;31(17):2053-2057. [Content Brief]

2-Desoxy-4-epi-pulchellin 相关分类

Others

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9947 mL	19.9736 mL	39.9473 mL	99.8682 mL
	5 mM	0.7989 mL	3.9947 mL	7.9895 mL	19.9736 mL
	10 mM	0.3995 mL	1.9974 mL	3.9947 mL	9.9868 mL
	15 mM	0.2663 mL	1.3316 mL	2.6632 mL	6.6579 mL
	20 mM	0.1997 mL	0.9987 mL	1.9974 mL	4.9934 mL
	25 mM	0.1598 mL	0.7989 mL	1.5979 mL	3.9947 mL
	30 mM	0.1332 mL	0.6658 mL	1.3316 mL	3.3289 mL
	40 mM	0.0999 mL	0.4993 mL	0.9987 mL	2.4967 mL
	50 mM	0.0799 mL	0.3995 mL	0.7989 mL	1.9974 mL
	60 mM	0.0666 mL	0.3329 mL	0.6658 mL	1.6645 mL
	80 mM	0.0499 mL	0.2497 mL	0.4993 mL	1.2484 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Desoxy-4-epi-pulchellin122872-03-1OthersInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

2-Desoxy-4-epi-pulchellin

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