2. GPCR/G Protein
  3. P2Y Receptor
  4. 2-MeSADP

2-MeSADP  (Synonyms: 2-Methylthioadenosine diphosphate; 2-Methylthio-ADP)

目录号: HY-108648A
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摩尔计算器

2-MeSADP (2-Methylthioadenosine diphosphate; 2-Methylthio-ADP) 是一种有效的嘌呤能 (P2Y) 受体激动剂，对人 P2Y13、小鼠 P2Y13 和人 P2Y12 的 EC50 分别为 19、6.2 和 5 nM。2-MeSADP 对人 P2Y1 和大鼠 P2Y6 的 pEC50 分别为 8.29 和 5.75。2-MeSADP 诱导血小板聚集和形态改变，并抑制前列腺素 E1 作用下血小板内环腺苷酸的积累。

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2-MeSADP Chemical Structure

2-MeSADP Chemical Structure

CAS No. : 34983-48-7

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Other Forms of 2-MeSADP:

2-MeSADP 相关抗体

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P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2-MeSADP (2-Methylthioadenosine diphosphate; 2-Methylthio-ADP) is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-MeSADP has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-MeSADP induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1[1][2][3].

IC50 & Target[1]

P2Y13 Receptor

19 nM (EC50)

P2Y12 Receptor

5 nM (EC50)

分子量

473.29

Formula

C11H17N5O10P2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2-MeSADP 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-MeSADP34983-48-72-Methylthioadenosine diphosphate 2-Methylthio-ADPP2Y ReceptorplateletaggregationshapechangecyclicAMPaccumulationsubtypesInhibitorinhibitorinhibit

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