2. GPCR/G Protein
  3. P2Y Receptor
  4. 2-Thio-UTP

2-Thio-UTP 是一种选择性的 P2Y2 抑制剂，其 EC50 值为 50 nM。2-Thio-UTP 可降低促纤维化基因表达和 α-平滑肌肌动蛋白的表达。2-Thio-UTP 具有用于研究钙化性主动脉瓣狭窄 (CAVS) 的潜力。

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2-Thio-UTP Chemical Structure

2-Thio-UTP Chemical Structure

CAS No. : 35763-29-2

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规格 是否有货
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100 mg   询价  
250 mg   询价  

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Other Forms of 2-Thio-UTP:

2-Thio-UTP 相关抗体

Top Publications Citing Use of Products

查看 P2Y Receptor 亚型特异性产品:

查看所有亚型
P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2-Thio-UTP is a selective P2Y2 inhibitor with an EC50 value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) [1][2].

IC50 & Target[1]

P2Y2 Receptor

50 nM (EC50)

体外研究
(In Vitro)

2-Thio-UTP (10 µM; 5 days) 可降低瓣膜间质细胞中 ACTA2、TGFB1、TGFB2、COL1A1、COL3A1 的 mRNA 表达，并降低 αSMA 的蛋白质[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2-Thio-UTP 相关抗体:

Western Blot Analysis[2]

Cell Line: valve interstitial cells
Concentration: 10 µM
Incubation Time: 5 days
Result: Reduced the αSMA protein expression.

RT-PCR[2]

Cell Line: valve interstitial cells
Concentration: 10 µM
Incubation Time: 5 days
Result: Significantly reduced the mRNA expression of ACTA2, TGFB1, TGFB2, COL1A1, COL3A1.
分子量

500.21

Formula

C9H15N2O14P3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2-Thio-UTP 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Thio-UTP35763-29-2P2Y ReceptorαSMAcalcific aortic valve stenosisvalve interstitial cellsInhibitorinhibitorinhibit

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产品名称：
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目录号：
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