2. Membrane Transporter/Ion Channel
  3. P2X Receptor
  4. BzATP triethylammonium

BzATP triethylammonium  (Synonyms: Benzoylbenzoyl-ATP triethylammonium)

目录号: HY-18745
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摩尔计算器

BzATP triethylammonium 是一种 P2X 受体激动剂，对 P2X1，P2X2，P2X3，P2X2/3，P2X4 和 P2X7 的 pEC50 分别为 8.74，5.26，7.10，7.50， 6.19，6.31 和 5.33。BzATP triethylammonium 对 P2X7 受体有效，对大鼠 P2X7 和小鼠 P2X7 的EC50 分别为 3.6 μM 和 285 μM。

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BzATP triethylammonium Chemical Structure

BzATP triethylammonium Chemical Structure

CAS No. : 112898-15-4

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Other Forms of BzATP triethylammonium:

BzATP triethylammonium 相关抗体

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P2X1 Receptor P2X2 Receptor P2X3 Receptor P2X4 Receptor P2X7 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BzATP triethylammonium acts as a P2X receptor agonist with pEC50s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively[1]. BzATP triethylammonium is potent at P2X7 receptors with EC50s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively[2].

IC50 & Target

pEC50: 8.74 (P2X1), 5.26 (P2X2), 7.10 (P2X3), 6.19 (P2X2/3), 6.31 (P2X4), 5.33 (P2X7)[1]
EC50 3.6 μM (rat P2X7); 285 μM (mouse P2X7)[2]
体外研究
(In Vitro)

BzATP (10-1000 μM；24 小时) triethylammonium 促进 U87 和 U251 胶质瘤细胞的增殖和迁移[3]。
BzATP (100 μM；6-48 小时) triethylammonium 在人类胶质瘤细胞中诱导 P2X7R 蛋白表达。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BzATP triethylammonium 相关抗体:

Cell Proliferation Assay[3]

Cell Line: U87 and U251 glioma cells
Concentration: 5, 10, 50, 100, 500 and 1000 μM
Incubation Time: 2, 6, 12, 24, 48 and 72 hours
Result: The proliferation of U87 and U251 glioma cell lines was significantly increased in the presence of 10-1000 uM and 100-1000 μM, respectively.
The peak of cell proliferation of both U87 and U251 cell lines was at 100 μM.
The optimal incubation time is 24 hours in both U87 and U251 cells lines.

Western Blot Analysis[3]

Cell Line: U87 and U251 glioma cells
Concentration: 100 μM
Incubation Time: 6-48 hours
Result: Induced the upregulation of P2X7R.
体内研究
(In Vivo)

与假手术组和对照组相比，在盲肠结扎穿刺 (CLP) 诱导后，BzATP (5 mg/kg) triethylammonium 显著促进肠道中 P2X7R 的表达[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male 2-month-old C57BL/6 mice (each weighing between 20 and 25 g)[4]
Dosage: 5 mg/kg
Administration: Injected through the intraperitoneal route
Result: At 48 hours, mice in the treated group and control group exhibited mortalities of 91% and 86%, respectively.
分子量

816.58

Formula

C30H39N6O15P3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

BzATP triethylammonium 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BzATP112898-15-4Benzoylbenzoyl-ATPP2X ReceptorP2XRsP2X1P2X2P2X3P2X2/3P2X4P2X7inflammatoryOvarianCarcinomaInhibitorinhibitorinhibit

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