2. Metabolic Enzyme/Protease
  3. Drug Metabolite Cytochrome P450
  4. 3-Hydroxyflunitrazepam

3-Hydroxyflunitrazepam  (Synonyms: 3-OH FNTZ)

目录号: HY-121057
产品使用指南 技术支持

3-Hydroxyflunitrazepam (3-OH FNTZ) 是 Flunitrazepam (FNTZ) 的主要代谢产物，由 CYP3A4 通过 3-羟基化途径生成 (Km = 286 μM)，在肝微粒体中占主导代谢途径 (>80%)。其生成受到 CYP3A4 抑制剂 如 Ketoconazole (HY-B0105) (IC50 = 0.11 μM) 和 Ritonavir (HY-90001) (IC50 = 0.041 μM) 的显著抑制。这表明 3-Hydroxyflunitrazepam 的代谢对 CYP3A4 的活性高度依赖，并可能受 CYP3A 抑制剂的药物相互作用影响。

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3-Hydroxyflunitrazepam Chemical Structure

3-Hydroxyflunitrazepam Chemical Structure

CAS No. : 67739-71-3

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3-Hydroxyflunitrazepam 相关抗体

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

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生物活性

3-Hydroxyflunitrazepam (3-OH FNTZ) is the major metabolite of Flunitrazepam (FNTZ), generated via 3-hydroxylation by CYP3A4 (Km = 286 μM), and represents the dominant metabolic pathway (>80%) in liver microsomes. Its formation is significantly inhibited by CYP3A4 inhibitors such as Ketoconazole (HY-B0105) (IC50 = 0.11 μM) and Ritonavir (HY-90001) (IC50 = 0.041 μM), indicating a strong dependence on CYP3A4 activity and potential drug interactions[1].

分子量

329.28

Formula

C16H12FN3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

3-Hydroxyflunitrazepam 相关分类

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Keywords:

3-Hydroxyflunitrazepam67739-71-33-OH FNTZDrug MetaboliteCytochrome P450CYPsInhibitorinhibitorinhibit

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