2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Cytoskeleton
  3. MDM-2/p53 Reactive Oxygen Species Apoptosis Annexin A Glutathione Reductase
  4. 3-Morpholinosydnonimine

3-Morpholinosydnonimine  (Synonyms: SIN-1; Linsidomine)

目录号: HY-126849
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摩尔计算器

3-Morpholinosydnonimine (SIN-1) 是一种自发的 ROS/RNS 发生器和过氧亚硝酸盐供体。3-Morpholinosydnonimine 可诱导氧化应激导致的软骨细胞凋亡 (apoptosis) 和坏死 (necrosis)。3-Morpholinosydnonimine 通过抑制膜联蛋白 A2 的表达，抑制血管平滑肌细胞迁移、增殖及新内膜形成。此外，低剂量的 3-Morpholinosydnonimine 对 Zn2+ 处理的神经细胞具有保护作用。

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3-Morpholinosydnonimine Chemical Structure

3-Morpholinosydnonimine Chemical Structure

CAS No. : 33876-97-0

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3-Morpholinosydnonimine 的其他形式现货产品:

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Other Forms of 3-Morpholinosydnonimine:

3-Morpholinosydnonimine 相关抗体

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AnxA2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3-Morpholinosydnonimine (SIN-1) is a spontaneous ROS/RNS generator and peroxynitrite donor. 3-Morpholinosydnonimine induces oxidative stress-induced chondrocyte apoptosis and necrosis. 3-Morpholinosydnonimine inhibits the migration, proliferation and neointima formation of vascular smooth muscle cells by inhibiting the expression of annexin A2. In addition, low doses of 3-Morpholinosydnonimine shows protective effects on Zn2+ treated nerve cells[1][2][3][4].

IC50 & Target[4]

AnxA2

 

体外研究
(In Vitro)

3-Morpholinosydnonimine (0-5 mM；0-24 小时) 可降低肥大软骨细胞的活力，诱导肥大软骨细胞坏死以及非肥大的 ATDC5 和 C28/I2 细胞凋亡[1]。
3-Morpholinosydnonimine (30-1000 μM；190 分钟) 阻止 Zn2+ 诱导的神经元死亡，但可被尿酸 (HY-B2130) 消除[2]。
3-Morpholinosydnonimine (100-300 μM；0-190 分钟) 在 PC12 细胞中增加活性氧和活性氮的产生，抑制 Zn2+ 诱导的谷胱甘肽还原酶失活和氧化谷胱甘肽/总谷胱甘肽比值的升高[2]。
3-Morpholinosydnonimine (1 mM；2-3 小时) 在 EAhy926 和 HUVECs 细胞中可诱导 Nrf2 的核积累[3]。
3-Morpholinosydnonimine (0-500 μM；30 分钟) 在大鼠主动脉平滑肌细胞中通过膜联蛋白 A2 抑制血小板源性生长因子 BB 诱导的细胞迁移和增殖[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3-Morpholinosydnonimine 相关抗体:

Cell Viability Assay[1]

Cell Line: Hypertrophic chondrocytes
Concentration: 0, 1, 2, 3, 4, 5 mM;
5 mM
Incubation Time: 24 h;
0, 4, 8, 12 and 24 h
Result: Reduced cellular viability of hypertrophic chondrocytes in a dose-dependent manner.
Reduced cellular viability of hypertrophic chondrocytes in a time-dependent manner.

Cell Viability Assay[2]

Cell Line: differentiated PC12 cells
Concentration: 30, 100, 300 and 1000 μM
Incubation Time: 190 min
Result: Blocked Zn2+-induced cell death in a concentration-dependent manner.
Had cytotoxic at higher concentrations than 1 mM.
体内研究
(In Vivo)

3-Morpholinosydnonimine (0.01-0.1 mg/kg；14 天) 可减轻球囊损伤大鼠颈动脉新生内膜的形成[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old male Sprague Dawley rats (180-190 g) with a balloon-injured carotid artery model[4]
Dosage: 0.01 and 0.1 mg/kg/day
Administration: 14 days
Result: Reduced the I/M (intima to media) ratio of the carotid artery in the group treated with 0.1 mg/kg/day.
Did not change the I/M ratio of the carotid artery in the group treated with 0.01 mg/kg/day.
分子量

170.17

Formula

C6H10N4O2
CAS 号
中文名称

林西多明
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

3-Morpholinosydnonimine 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

3-Morpholinosydnonimine33876-97-0SIN-1 Linsidomine林西多明SIN1SIN 1MDM-2/p53Reactive Oxygen SpeciesApoptosisAnnexin AGlutathione ReductaseAnxABalloon-injured rat carotid arteriesPC12 cellsEAhy926 cellsHUVECs cellsVascular smooth muscle cellsInhibitorinhibitorinhibit

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