2. Epigenetics Stem Cell/Wnt MAPK/ERK Pathway Cytoskeleton TGF-beta/Smad Cell Cycle/DNA Damage
  3. ROCK p38 MAPK PKC
  4. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine 

目录号: HY-N12466
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摩尔计算器

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) 是一种蛋白激酶抑制剂，对 PKC-α、ROCK、ASK1 的 IC50 为 0.092, 0.26, 0.77 μM。3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine 对 PC-3 癌细胞具有有效的细胞毒性，IC50 值为 0.16 μM。

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3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine Chemical Structure

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine Chemical Structure

CAS No. : 2226941-29-1

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3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine 相关抗体

Top Publications Citing Use of Products

查看 ROCK 亚型特异性产品:

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ROCK ROCK1 ROCK2

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 PKC 亚型特异性产品:

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is an inhibitor of protein kinases, with IC50s of 0.092, 0.26, 0.77 μM for PKC-α, ROCK, ASK1. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine shows potent cytotoxicity against PC-3 cancer cells with an IC50 value of 0.16 μM[1].

分子量

480.51

Formula

C28H24N4O4
CAS 号
结构分类
初始来源

Streptomyces sp
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine2226941-29-1ROCKp38 MAPKPKCRho-associated protein kinaseRho-associated kinaseRho-kinaseROKProtein kinase CInhibitorinhibitorinhibit

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