2. Metabolic Enzyme/Protease Membrane Transporter/Ion Channel Autophagy
  3. HMG-CoA Reductase (HMGCR) Potassium Channel Autophagy
  4. (3R,5R)-Rosuvastatin

(3R,5R)-Rosuvastatin 是 Rosuvastatin 的 (3R,5R) 对映体。Rosuvastatin 是一种竞争性 HMG-CoA 还原酶抑制剂，IC50 为 11 nM。Rosuvastatin 有效阻断人类醚-a-go-go 相关基因 (hERG) 电流，IC50 为 195 nM。Rosuvastatin 降低成熟 hERG 的表达以及 Hsp70 与 hERG 蛋白的相互作用。Rosuvastatin 有效降低低密度脂蛋白 (LDL) 胆固醇，甘油三酯和 C-反应蛋白水平。

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(3R,5R)-Rosuvastatin Chemical Structure

(3R,5R)-Rosuvastatin Chemical Structure

CAS No. : 1094100-06-7

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(3R,5R)-Rosuvastatin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM[2]. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[3].

IC50 & Target

IC50: 11 nM (HMG-CoA)[1] and 195 nM (hERG)[2]
分子量

481.54

Formula

C22H28FN3O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(3R,5R)-Rosuvastatin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(3R,5R)-Rosuvastatin1094100-06-7HMG-CoA Reductase (HMGCR)Potassium ChannelAutophagyKcsA(3R,5R)-enantiomerhERGHsp70LDL-CC-reactivetriglyceridesInhibitorinhibitorinhibit

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