2. Autophagy Metabolic Enzyme/Protease Anti-infection Membrane Transporter/Ion Channel Others
  3. Autophagy Potassium Channel Bacterial HMG-CoA Reductase (HMGCR) Isotope-Labeled Compounds
  4. Rosuvastatin-13C,d3 sodium

Rosuvastatin-13C,d3 sodium  (Synonyms: ZD 4522-13C,d3 sodium; X-Plended-13C,d3 sodium; Crestor-13C,d3 sodium)

目录号: HY-17504BS2
产品使用指南

摩尔计算器

Rosuvastatin-13C,d3 sodium 是 13C 和氘代标记的 Rosuvastatin sodium (HY-17504B)。Rosuvastatin Sodium 是一种竞争性 HMG-CoA 还原酶 (HMGCR) 抑制剂，IC50 为11 nM。Rosuvastatin Sodium 有效阻断 hERG 电流，IC50 为 195 nM。Rosuvastatin Sodium 降低成熟 hERG 的表达以及热休克蛋白 70 (Hsp70) 与 hERG 蛋白的相互作用。Rosuvastatin Sodium 有效降低低密度脂蛋白 (LDL) 胆固醇，甘油三酯和 C- 反应蛋白水平。

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Rosuvastatin-<sub>13</sub>C,d<sub>3</sub> sodium Chemical Structure

Rosuvastatin-13C,d3 sodium Chemical Structure

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Rosuvastatin-13C,d3 sodium 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rosuvastatin-13C,d3 sodium is 13C and deuterated labeled Rosuvastatin sodium (HY-17504B). Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM[2]. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[1][2][3].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Rosuvastatin-13C,d3 sodium 相关抗体:
体内研究
(In Vivo)

Rosuvastatin Sodium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms[3].
Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins Sodium (VLDL) in diabetes mellitus rats induced by Streptozocin[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

507.53

Formula

C2113CH24D3FN3NaO6S
非标记 CAS

147098-18-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Rosuvastatin-13C,d3 sodium 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rosuvastatin-13C,d3ZD 4522-13C,d3X-Plended-13C,d3Crestor-13C,d3AutophagyPotassium ChannelBacterialHMG-CoA Reductase (HMGCR)Isotope-Labeled CompoundsKcsAhERGcardiacrepolarizationactionpotentialdurationsAPDsQTQTcHsp70low-densitylipoproteincholesteroltriglyceridesInhibitorinhibitorinhibit

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