2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. 4β-Hydroxywithanolide E

4β-Hydroxywithanolide E 可从 Physalis peruviana L.中分离得到，可通过调节有丝分裂克隆扩增来抑制 3T3-L1 细胞的脂肪细胞分化。4β-Hydroxywithanolide E 是一种脂肪生成抑制剂，可抑制 PPARγ、C/EBPα 和脂肪细胞特异性分子 aP2 mRNA 的表达。

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4β-Hydroxywithanolide E Chemical Structure

4β-Hydroxywithanolide E Chemical Structure

CAS No. : 54334-04-2

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规格 价格 是否有货 数量
1 mg ￥6120
1 - 2 周
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4β-Hydroxywithanolide E 相关抗体

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PPARα PPARβ/δ PPARγ PPAR PPARδ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4β-Hydroxywithanolide E, isolated from Physalis peruviana L., inhibits adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. 4β-Hydroxywithanolide E is an adipogenesis inhibitor and inhibits PPARγ, C/EBPα, and the adipocyte-specific molecule aP2 mRNA expression[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
ACHN IC50
> 2 μM
Compound: 12
Cytotoxicity against human ACHN cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay
Cytotoxicity against human ACHN cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay
[PMID: 28617598]
ACHN IC50
563 nM
Compound: 5
Sensitization of TRAIL-induced apoptosis in human ACHN cells assessed as reduction in cell viability preincubated for 2 hrs followed by addition of TRAIL measured after 18 hrs by MTS assay
Sensitization of TRAIL-induced apoptosis in human ACHN cells assessed as reduction in cell viability preincubated for 2 hrs followed by addition of TRAIL measured after 18 hrs by MTS assay
[PMID: 28257574]
CWR22R IC50
0.09 μM
Compound: 12
Cytotoxicity against human 22Rv1 cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay
Cytotoxicity against human 22Rv1 cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay
[PMID: 28617598]
HEK293 IC50
0.04 μM
Compound: 4
Inhibition of TNFalpha-activated nuclear factor-kappa B activity (unknown origin) expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene based assay
Inhibition of TNFalpha-activated nuclear factor-kappa B activity (unknown origin) expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene based assay
[PMID: 27210437]
HFF IC50
> 2 μM
Compound: 12
Cytotoxicity against HFF cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay
Cytotoxicity against HFF cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay
[PMID: 28617598]
LNCaP IC50
0.16 μM
Compound: 12
Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay
Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay
[PMID: 28617598]
M14 IC50
> 2 μM
Compound: 12
Cytotoxicity against human M14 cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay
Cytotoxicity against human M14 cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay
[PMID: 28617598]
MCF7 GI50
1 μM
Compound: 2
Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by SRB assay
[PMID: 20438092]
MDA-MB-231 GI50
2.1 μM
Compound: 2
Antiproliferative activity against estrogen receptor deficient human MDA-MB-231 cells after 48 hrs by SRB assay
Antiproliferative activity against estrogen receptor deficient human MDA-MB-231 cells after 48 hrs by SRB assay
[PMID: 20438092]
RAW264.7 IC50
0.32 μM
Compound: 4
Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 30 mins before LPS stimulation for 20 hrs by Griess reagent based assay
Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 30 mins before LPS stimulation for 20 hrs by Griess reagent based assay
[PMID: 27210437]
RAW264.7 IC50
1.8 μM
Compound: 1
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 30 mins followed by LPS challenge and measured after 18 hrs by Griess assay
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 30 mins followed by LPS challenge and measured after 18 hrs by Griess assay
[PMID: 30649869]
SK-BR-3 GI50
1.7 μM
Compound: 2
Antiproliferative activity against estrogen receptor deficient human SKBR3 cells after 48 hrs by SRB assay
Antiproliferative activity against estrogen receptor deficient human SKBR3 cells after 48 hrs by SRB assay
[PMID: 20438092]
SK-MEL-28 IC50
> 2 μM
Compound: 12
Cytotoxicity against human SK-MEL-28 cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay
Cytotoxicity against human SK-MEL-28 cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay
[PMID: 28617598]
T47D GI50
2.2 μM
Compound: 2
Antiproliferative activity against human T47D cells expressing estrogen receptor after 48 hrs by SRB assay
Antiproliferative activity against human T47D cells expressing estrogen receptor after 48 hrs by SRB assay
[PMID: 20438092]
分子量

502.60

Formula

C28H38O8
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4β-Hydroxywithanolide E 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4β-Hydroxywithanolide E54334-04-2PPARPeroxisome proliferator-activated receptorsadipocyte differentiationadipogenesis inhibitorPPARγC/EBPαadipocyte-specific molecule aP2 mRNA expressionInhibitorinhibitorinhibit

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