2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Estrogen Receptor/ERR Drug Metabolite
  4. 4'-Hydroxytamoxifen

4'-Hydroxytamoxifen 

目录号: HY-124414 纯度: 99.2%
COA 产品使用指南

摩尔计算器

4'-Hydroxytamoxifen 是 Tamoxifen 的代谢物。4'-Hydroxytamoxifen 对 ER 的亲和力高于 Tamoxifen。4'-Hydroxytamoxifen 在人子宫内膜腺癌细胞中诱导非凋亡细胞毒性。

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4'-Hydroxytamoxifen Chemical Structure

4'-Hydroxytamoxifen Chemical Structure

CAS No. : 82413-23-8

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规格 价格 是否有货 数量
1 mg ￥3501
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

Other Forms of 4'-Hydroxytamoxifen:

4'-Hydroxytamoxifen 相关抗体

Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

查看所有亚型
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4'-Hydroxytamoxifen is a metabolite of Tamoxifen. 4'-Hydroxytamoxifen shows higher affinity for the ER than Tamoxifen. 4'-Hydroxytamoxifen induces a non-apoptotic cytotoxic effect in human endometrial adenocarcinoma cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
0.0033 μM
Compound: 4-OHT
Antiproliferative activity against human MCF7 cells after 5 days by coulter counter analysis
Antiproliferative activity against human MCF7 cells after 5 days by coulter counter analysis
[PMID: 27529700]
MCF7 IC50
22 μM
Compound: 4-OHT
Antiproliferative activity against human tamoxifen-resistant MCF7 cells after 5 days by coulter counter analysis
Antiproliferative activity against human tamoxifen-resistant MCF7 cells after 5 days by coulter counter analysis
[PMID: 27529700]
MCF7 IC50
9.5 μM
Compound: 4-OHT
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32283297]
T47D IC50
0.024 μM
Compound: 4-OHT
Antiproliferative activity against human T47D cells after 5 days by coulter counter analysis
Antiproliferative activity against human T47D cells after 5 days by coulter counter analysis
[PMID: 27529700]
T47D IC50
0.54 μM
Compound: 4-OHT
Antiproliferative activity against human tamoxifen-resistant T47D cells over-expressing PKC-alpha after 5 days by coulter counter analysis
Antiproliferative activity against human tamoxifen-resistant T47D cells over-expressing PKC-alpha after 5 days by coulter counter analysis
[PMID: 27529700]
分子量

387.51

Formula

C26H29NO2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMF 中的溶解度 : 20 mg/mL (51.61 mM; 超声加热助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5806 mL 12.9029 mL 25.8058 mL
5 mM 0.5161 mL 2.5806 mL 5.1612 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.2%

COA (288 KB)

产品使用指南 (1538 KB)
参考文献

4'-Hydroxytamoxifen 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 2.5806 mL 12.9029 mL 25.8058 mL 64.5145 mL
5 mM 0.5161 mL 2.5806 mL 5.1612 mL 12.9029 mL
10 mM 0.2581 mL 1.2903 mL 2.5806 mL 6.4514 mL
15 mM 0.1720 mL 0.8602 mL 1.7204 mL 4.3010 mL
20 mM 0.1290 mL 0.6451 mL 1.2903 mL 3.2257 mL
25 mM 0.1032 mL 0.5161 mL 1.0322 mL 2.5806 mL
30 mM 0.0860 mL 0.4301 mL 0.8602 mL 2.1505 mL
40 mM 0.0645 mL 0.3226 mL 0.6451 mL 1.6129 mL
50 mM 0.0516 mL 0.2581 mL 0.5161 mL 1.2903 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4'-Hydroxytamoxifen82413-23-8Estrogen Receptor/ERRDrug MetaboliteInhibitorinhibitorinhibit

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目录号：
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