5-Aminolevulinic acid-d₂ hydrochloride  (Synonyms: 5-氨基乙酰丙酸盐酸盐-d₂; 5-ALA-d₂ hydrochloride; δ-Aminolevulinic acid-d₂ hydrochloride; 5-Amino-4-oxopentanoic acid-d₂ hydrochloride)

5-Aminolevulinic acid-d₂ (hydrochloride) is deuterium labeled 5-Aminolevulinic acid (hydrochloride).

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

169.60

C₅H₈D₂ClNO₃

187237-35-0

5451-09-2

固体

Off-white to light yellow

5-氨基乙酰丙酸盐酸盐-d₂

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. Stummer, W., et al., Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol, 2006. 7(5): p. 392-401.  [Content Brief]

  [3]. Eyupoglu, I.Y., et al., Improving the extent of malignant glioma resection by dual intraoperative visualization approach. PLoS One, 2012. 7(9): p. e44885.  [Content Brief]