2. Apoptosis
  3. Apoptosis
  4. 5-OH-HxMF

5-OH-HxMF 是一种羟基化的聚甲氧基黄酮，具有抗炎、抗癌、神经营养和神经保护活性。

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5-OH-HxMF Chemical Structure

5-OH-HxMF Chemical Structure

CAS No. : 1176-88-1

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5-OH-HxMF 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

5-OH-HxMF is a hydroxylated polymethoxyflavone that has anti-inflammatory, anticancer, neurotrophic and neuroprotective activities[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HL-60 IC50
4.16 μM
Compound: IV, 5-demethylheptaMF
Antiproliferative activity against HL60 after 24 hrs
Antiproliferative activity against HL60 after 24 hrs
[PMID: 17391969]
Monocyte IC50
10 μM
Compound: 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone
Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA
Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA
[PMID: 10096854]
体外研究
(In Vitro)

5-OH-HxMF（5-20 µM；48 小时）有效诱导 PC12 神经突生长，并伴有神经元分化标记蛋白生长相关蛋白 43(GAP-43)的表达[1] 。
5-OH-HxMF（20 µM；0-120 分钟）导致环 AMP 反应元件结合蛋白 (CREB) 磷酸化、c-fos 基因表达和 CRE 介导的转录增强[1]。
5-OH-HxMF 显着减少一氧化氮和前列腺素 E2 的产生，并下调脂多糖 (LPS) 刺激的 RAW 264.7 细胞中的诱导型一氧化氮合酶 (iNOS) 和 COX-2 表达。5-OH-HxMF 抑制促炎细胞因子的释放，例如肿瘤坏死因子-α 和 IL-1β，并降低转录水平。5-OH-HxMF 显着抑制 LPS 诱导的 NF-κB 从细胞质向细胞核的易位，这与抑制性 IκBα 降解的消除和随后核 p65 水平的降低有关[2]。
5-OH-HxMF 在人白血病细胞中抑制细胞生长并诱导细胞凋亡[3]。 PC12 cells 10 µM, 20 µM 24 h Promoted GAP-43 expression in PC12 cells. PC12 cells 20 µM 0 min, 30 min, 60 min or 120 min Stimulated phosphorylation of CREB in PC12 cells.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

5-OH-HxMF 相关抗体:

Cell Viability Assay[1]

Cell Line: PC12 cells
Concentration: 5 µM, 10 µM, 20 µM
Incubation Time: 48 h
Result: Significantly evoked a dose-dependent increase on neurite outgrowth.

Western Blot Analysis[1]

Cell Line: PC12 cells
Concentration: 5 µM, 10 µM, 20 µM
Incubation Time: 24 h
Result: Promoted GAP-43 expression in PC12 cells.

Western Blot Analysis[1]

Cell Line: PC12 cells
Concentration: 20 µM
Incubation Time: 0 min, 30 min, 60 min or 120 min
Result: Stimulated phosphorylation of CREB in PC12 cells.
体内研究
(In Vivo)

5-OH-HxMF（局部处理；每周两次；20 周；200 μL 丙酮中 1 和 3 μmol）是一种有效的抗肿瘤剂，其抑制作用是通过下调炎症 iNOS 和 COX-2 基因表达在小鼠皮肤中[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female ICR mice treated with 12-O-tetradecanoylphorbol-13-acetate (TPA)[3].
Dosage: 1 and 3 μmol in 200 μL acetone
Administration: Topically treated; twice a week; for 20 weeks
Result: Significantly inhibited TPA-induced mouse skin inflammation by decreasing inflammatory parameters.
分子量

418.39

Formula

C21H22O9
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

5-OH-HxMF 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-OH-HxMF1176-88-1Apoptosisanti-inflammatoryanticancerneurotrophic and neuroprotective activitiespolymethoxyflavoneInhibitorinhibitorinhibit

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