1. Metabolic Enzyme/Protease
  2. Phospholipase MAGL
  3. 7-Hydroxycoumarinyl arachidonate

7-Hydroxycoumarinyl arachidonate  (Synonyms: 7-HCA; Umbelliferyl Arachidonate; 7-HC-arachidonate)

目录号: HY-116141 纯度: ≥98.0%
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7-Hydroxycoumarinyl arachidonate (7-HCA) 是胞质磷脂酶 A2 (PLA2) 的荧光底物,也是单酰基甘油脂肪酶 (MAGL) 的荧光底物。MAGL 蛋白催化 7-Hydroxycoumarinyl arachidonate 的水解,生成花生四烯酸 (AA;HY-109590) 和高荧光的 7-羟基香豆素 (7-HC;HY-N0573),7-HC 的释放可以用荧光计进行测量。

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7-Hydroxycoumarinyl arachidonate Chemical Structure

7-Hydroxycoumarinyl arachidonate Chemical Structure

CAS No. : 161180-11-6

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5 mg (55.73 mM * 200 μl ethanol) ¥1000
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

7-Hydroxycoumarinyl arachidonate (7-HCA) is a fluorogenic substrate of cytosolic phospholipase A2 (PLA2). 7-Hydroxycoumarinyl arachidonate is also a fluorogenic substrate for monoacylglycerol lipase (MAGL). MAGL protein catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonat to generate Arachidonic acid (AA) and the highly fluorescent 7-hydroxyl coumarin (7-HC; HY-N0573). Release of 7-HC can be measured using a fluorometer[1][2][3].

体外研究
(In Vitro)

MAGL catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonate (7-HCA) into arachidonic acid (AA) and 7-HC. Release of 7-HC, which is fluorescent, is monitored over time with excitation (Ex) at 355 nm and emission (Em) at 460 nm[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

448.59

Formula

C29H36O4

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years

纯度 & 产品资料

纯度: ≥98.0%

参考文献

7-Hydroxycoumarinyl arachidonate 相关分类

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产品名称:
7-Hydroxycoumarinyl arachidonate
目录号:
HY-116141
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