2. Metabolic Enzyme/Protease Neuronal Signaling
  3. Monoamine Oxidase Cytochrome P450
  4. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate 

目录号: HY-134664
产品使用指南

摩尔计算器

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate 是一种不可逆的 CYP2A6?抑制剂，预孵育和共孵育的 IC50 分别为 8.64 μM 和 22.3 μM。8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate 也抑制 MAO-A 和 MAO-B，IC50 分别为 60.2 和 38.6 μM。

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8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate Chemical Structure

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate Chemical Structure

CAS No. : 67667-71-4

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8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC50s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC50s of 60.2 and 38.6 μM, respectively[1].

IC50 & Target

IC50: 8.64 μM (CYP2A6, pre-incubation), 22.3 μM (CYP2A6, co-incubation), 38.6 μM (MAO-B), 60.2 μM(MAO-A)[1]
Ki: 15.1 μM (CYP2A6), 27.2 μM (MAO-B), 60.2 μM (MAO-A)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
5.2 μM
Compound: 5
Inhibition of TNFalpha-induced NF-kappaB activity expressed in human HEK 293 cells after 6 hrs by luciferase reporter gene assay
Inhibition of TNFalpha-induced NF-kappaB activity expressed in human HEK 293 cells after 6 hrs by luciferase reporter gene assay
[PMID: 22850207]
MCF7 IC50
7.7 μM
Compound: 7
Antiproliferative activity against human MCF7 cells for 72 hrs by cyquant assay
Antiproliferative activity against human MCF7 cells for 72 hrs by cyquant assay
[PMID: 26331426]
MDA-MB-231 IC50
5.2 μM
Compound: 7
Antiproliferative activity against human MDA-MB-231 cells for 72 hrs by cyquant assay
Antiproliferative activity against human MDA-MB-231 cells for 72 hrs by cyquant assay
[PMID: 26331426]
NIH3T3 IC50
7.1 μM
Compound: 7
Cytotoxicity against mouse NIH/3T3 cells after 72 hrs by cyquant cells
Cytotoxicity against mouse NIH/3T3 cells after 72 hrs by cyquant cells
[PMID: 26331426]
RAW264.7 IC50
6.6 μM
Compound: 5
Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method
Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method
[PMID: 22850207]
SF-295 IC50
9.1 μM
Compound: 7
Antiproliferative activity against human SF295 cells for 72 hrs by cyquant assay
Antiproliferative activity against human SF295 cells for 72 hrs by cyquant assay
[PMID: 26331426]
U-251 IC50
2.6 μM
Compound: 7
Antiproliferative activity against human U251MG cells for 72 hrs by cyquant assay
Antiproliferative activity against human U251MG cells for 72 hrs by cyquant assay
[PMID: 26331426]
U-373MG ATCC IC50
8.3 μM
Compound: 7
Antiproliferative activity against human U373MG cells for 72 hrs by cyquant assay
Antiproliferative activity against human U373MG cells for 72 hrs by cyquant assay
[PMID: 26331426]
分子量

406.43

Formula

C21H26O8
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate67667-71-4Monoamine OxidaseCytochrome P450MAOCYPsP4502A6CYP2A6Vernonia cinereaasthmabronchitisInhibitorinhibitorinhibit

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