2. Immunology/Inflammation
  3. NO Synthase
  4. 8A8

8A8 是一种有效的促炎因子 NO 抑制剂，IC50 为 4.7 μM。8A8 还显著抑制 LPS 诱导的 HaCat 细胞增殖。

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8A8 Chemical Structure

8A8 Chemical Structure

CAS No. : 2766594-12-9

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8A8 相关抗体

Top Publications Citing Use of Products

查看 NO Synthase 亚型特异性产品:

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nNOS iNOS eNOS

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

8A8 is a potent proinflammatory factor NO inhibitor with an IC50 of 4.7 μM. 8A8 also significantly inhibits LPS-induced HaCat cell proliferation[1].

体外研究
(In Vitro)

Low concentrations of compound 8A8 (2.5 μM; RAW 264.7 cells) could significantly down-regulate IL-6 and TNF-α in cellular emotional intelligence, IL-6 and TNF-α are only half of those after LPS treatment at 5 μM, and IL-6 and TNF-α in cell supernatants were only a quarter of those after LPS treatment after high concentration compound 8A8 (10 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

8A8 相关抗体:
分子量

799.06

Formula

C36H37BrClN5O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

8A8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8A82766594-12-9NO SynthaseNitric oxide synthasesNOSIL-6TNF-αRAW 264.7 cellsLPSHaCat proliferationInhibitorinhibitorinhibit

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目录号：
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