2. PROTAC
  3. PROTAC Linkers
  4. 9-Decyn-1-ol

9-Decyn-1-ol 是一种 PROTAC linker，属于 alkyl/ether 类，可用于合成一系列 PROTAC 分子，如 9-Decyn-1-ol 将 GDC-0068 和 Lenalidomide 偶联可合成 INY-03-041 (HY-133120)。INY-03-041 是一种有效的选择性 PROTAC Akt 降解剂。INY-03-041 抑制 Akt1，Akt2 和 Akt3，IC50 分别为 2.0 nM，6.8 nM 和 3.5 nM。9-Decyn-1-ol 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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9-Decyn-1-ol Chemical Structure

9-Decyn-1-ol Chemical Structure

CAS No. : 17643-36-6

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规格 价格 是否有货
1 g ￥169
询问价格 & 货期
5 g ￥643
询问价格 & 货期
10 g ￥1182
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9-Decyn-1-ol 相关抗体

Top Publications Citing Use of Products

查看 PROTAC Linkers 亚型特异性产品:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively[1]. 9-Decyn-1-ol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

Alkyl/ether

 

体外研究
(In Vitro)

9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide by a linker[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

9-Decyn-1-ol 相关抗体:
分子量

154.25

Formula

C10H18O
CAS 号
性状

液体（密度：0.87 g/cm3）

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

9-Decyn-1-ol 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

9-Decyn-1-ol17643-36-6PROTAC LinkersalkyletherGDC-0068LenalidomideINY-03-041AktdegraderInhibitorinhibitorinhibit

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产品名称：
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目录号：
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